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Titolo:
VAGOVAGAL INHIBITION OF MOTILIN-INDUCED PHASE-III CONTRACTIONS BY ANTRAL ACIDIFICATION IN DOG STOMACH
Autore:
YAMAMOTO O; MATSUNAGA Y; HAGA N; ITOH Z;
Indirizzi:
GUNMA UNIV,INST ENDOCRINOL,GASTROINTESTINAL RES LABS MAEBASHI GUMMA 371 JAPAN GUNMA UNIV,INST ENDOCRINOL,GASTROINTESTINAL RES LABS MAEBASHI GUMMA 371 JAPAN
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 267, anno: 1994,
parte:, 1
pagine: 70000129 - 70000134
SICI:
0002-9513(1994)267:1<70000129:VIOMPC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID SECRETORY RESPONSES; ANESTHETIZED FERRET; AFFERENT NEURONS; MOTOR-ACTIVITY; RAT STOMACH; RECEPTORS; DISEASE; FIBERS;
Keywords:
GASTROINTESTINAL TRACT; GASTRIC ACID SECRETION; VAGAL AFFERENTS; VAGOVAGAL REFLEX; GASTROINTESTINAL MOTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
O. Yamamoto et al., "VAGOVAGAL INHIBITION OF MOTILIN-INDUCED PHASE-III CONTRACTIONS BY ANTRAL ACIDIFICATION IN DOG STOMACH", The American journal of physiology, 267(1), 1994, pp. 70000129-70000134

Abstract

Gastric acidification at pH 1.0 strongly inhibits the spontaneously occurring and motilin-induced phase III contractions in canine and human stomach. In this study, we examined inhibition by gastric acidification in dogs following gastrojejunostomy, truncal vagotomy, and antrectomy. As a result, gastric acidification with 0.1 N HCl solution at pH 1.0 for 30 min at a rate of 1.0 ml/min significantly inhibited motilin-induced phase III activity to 23.5 +/- 5.9% of the control in the normal intact dogs and to 17.2 +/- 3.4% in the gastrojejunostomized dogs. In the antrectomized dogs, gastric acidification did not significantly inhibit the action of motilin (81.7 +/- 10%), but, in the vagotomized dogs, gastric acidification inhibited the action of motilin to 72.0 /- 4.9%; the inhibition was much weaker than in the intact and gastrojejunostomized dogs but was significant. The duodenal acidification had no effect at all on the action of motilin (94.6 +/- 12.5%) in the gastrojejunostomized dogs. These findings strongly suggest the existenceof a vagovagal reflex in the inhibition of motilin-induced phase III contractions by gastric antral acidification, although the involvementof sympathetic regulation cannot be completely ruled out.

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Documento generato il 30/09/20 alle ore 23:44:32