Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RACE, SEX, AND PUBERTY INFLUENCE ONSET, SEVERITY, AND OUTCOME IN JUVENILE MYASTHENIA-GRAVIS
Autore:
ANDREWS PI; MASSEY JM; HOWARD JF; SANDERS DB;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PEDIAT,DIV PEDIAT NEUROL,BOX 3533 DURHAM NC 27710 UNIV N CAROLINA,DEPT NEUROL CHAPEL HILL NC 00000 DUKE UNIV,MED CTR,DEPT MED DURHAM NC 27710
Titolo Testata:
Neurology
fascicolo: 7, volume: 44, anno: 1994,
pagine: 1208 - 1214
SICI:
0028-3878(1994)44:7<1208:RSAPIO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATIC DISEASES; OPEN TIME; UK DATA; THYMECTOMY; ACETYLCHOLINE; CHILDREN; ARTHRITIS; INFANTILE; FEATURES; PAUCITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P.I. Andrews et al., "RACE, SEX, AND PUBERTY INFLUENCE ONSET, SEVERITY, AND OUTCOME IN JUVENILE MYASTHENIA-GRAVIS", Neurology, 44(7), 1994, pp. 1208-1214

Abstract

We assessed the influence of race, sex, and puberty upon clinical features and outcome in 115 patients with autoimmune juvenile myasthenia gravis (JMG). These demographic variables influenced not only disease incidence but also disease severity, response to therapy, and outcome,despite comparable therapeutic strategies. Among white patients, those with prepubertal onset had low incidence and equal sex ratio; the incidence in females increased during and after puberty; males had lesser disease severity than females during and after puberty (p < 0.05); spontaneous remissions were most frequent (44%, p = 0.001) and persistence of active JMG for more than 10 years was least frequent (p = 0.05)in patients with prepubertal onset; remissions were more frequent after early than late thymectomy (p = 0.03); and final disease severity was less after early than late thymectomy. Black patients had similar incidence, disease severity, and sex ratio (F:M = 2:1) with pre-, peri-, or postpubertal disease onset; infrequent spontaneous or treatment-induced remissions; and the same final disease severity after early or late thymectomy. These observations imply that race and sex hormones modify the clinical features and outcome of JMG; spontaneous remissionsare common in white patients with prepubertal disease onset; early thymectomy may be more beneficial than late thymectomy in white patients; and the role of thymectomy in the youngest patients is uncertain. Wesuggest that demographic factors should be considered when evaluatingpast and future therapeutic strategies for JMG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:33:28