Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PHARMACOLOGICAL DISSOCIATION OF RESPONSES TO CCK AND GASTRIC LOADS INRAT MECHANOSENSITIVE VAGAL AFFERENTS
Autore:
SCHWARTZ GJ; MCHUGH PR; MORAN TH;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,720 RUTLAND AVE,ROSS BLDG,RM 618 BALTIMORE MD 21205
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 267, anno: 1994,
parte:, 2
pagine: 180000303 - 180000308
SICI:
0002-9513(1994)267:1<180000303:PDORTC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; RECEPTOR ANTAGONISTS; VAGUS NERVE; FOOD-INTAKE; CHOLECYSTOKININ; SATIETY; TRANSPORT; INVITRO; PYLORUS;
Keywords:
CHOLECYSTOKININ TYPE A RECEPTOR ANTAGONIST; CHOLECYSTOKININ TYPE B RECEPTOR ANTAGONIST; DEVAZEPIDE; L-364,718; L-365,260; GASTRIC DISTENSION; CCK-JMV-180; ATROPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Schwartz et al., "PHARMACOLOGICAL DISSOCIATION OF RESPONSES TO CCK AND GASTRIC LOADS INRAT MECHANOSENSITIVE VAGAL AFFERENTS", The American journal of physiology, 267(1), 1994, pp. 180000303-180000308

Abstract

To identify the transduction mechanisms underlying gastric vagal afferent responses to gastric loads and cholecystokinin (CCK), we investigated the ability of specific CCK antagonists, acute pylorectomy, and cholinergic blockade to effect these vagal afferent responses. The CCK-B antagonist L-365,260 (10 pmol-1 nmol) failed to block the gastric vagal afferent response to gastric loads or 100 pmol CCK, while the CCK-A antagonist devazepide (100 pmol-100 nmol) competitively and dose dependently attenuated the response to CCK but not to gastric loads. Application of 100 nmol of the low-affinity CCK receptor antagonist CCK-JMV-180 also completely blocked the gastric vagal afferent response to 100 pmol CCK. Acute pylorectomy failed to block the gastric vagal afferent response to 100 pmol CCK or 2-ml gastric loads. Atropine sulfate administration (15 mg/rat) failed to block the gastric vagal afferent response to 100 pmol CCK or 2-ml gastric loads. These data suggest that1) the vagal afferent response to CCK is mediated through CCK's interactions with vagal, rather than pyloric, CCK-A receptors, and 2) the vagal afferent responses to CCK and to gastric loads are mediated by dissociable, possibly independent, transduction mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:03:36