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Titolo:
TEMPORAL CASCADE OF PLASMA-LEVEL SURGES IN ACTH, CORTICOSTERONE, AND CYTOKINES IN ENDOTOXIN-CHALLENGED RATS
Autore:
GIVALOIS L; DORNAND J; MEKAOUCHE M; SOLIER MD; BRISTOW AF; IXART G; SIAUD P; ASSENMACHER I; BARBANEL G;
Indirizzi:
UNIV MONTPELLIER 2,ENDOCRINOL NEUROBIOL LAB,CNRS,URA 1197 F-34095 MONTPELLIER FRANCE UNIV MONTPELLIER 2,ENDOCRINOL NEUROBIOL LAB,CNRS,URA 1197 F-34095 MONTPELLIER FRANCE UNIV MONTPELLIER 2,MICROBIOL & BACTERIAL IMMUN LAB,INSERM,U65 F-34095MONTPELLIER FRANCE NATL INST BIOL STAND & CONTROLS POTTERS BAR EN6 3QG HERTS ENGLAND
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 267, anno: 1994,
parte:, 2
pagine: 180000164 - 180000170
SICI:
0002-9513(1994)267:1<180000164:TCOPSI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; FACTOR-ALPHA; PRODUCTION INVIVO; MEDIAN-EMINENCE; WHOLE-BLOOD; INTERLEUKIN-1; CELLS; GLUCOCORTICOIDS;
Keywords:
ENDOTOXIN SHOCK; PATHOPHYSIOLOGY OF INFECTIONS; CYTOKINES; IMMUNONEUROENDOCRINOLOGY; STRESS; HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS; INTERLEUKIN-1-BETA; INTERLEUKIN-6; TUMOR NECROSIS FACTOR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
L. Givalois et al., "TEMPORAL CASCADE OF PLASMA-LEVEL SURGES IN ACTH, CORTICOSTERONE, AND CYTOKINES IN ENDOTOXIN-CHALLENGED RATS", The American journal of physiology, 267(1), 1994, pp. 180000164-180000170

Abstract

The present study was designed to investigate the coupling mechanismslinking the immune and the neuroendocrine corticotropic systems in anintegrated defense response triggered by an infectious aggression. The experimental paradigm used consisted of the exploration in individual conscious rats of the temporal pattern of increased plasma concentrations of the two stress hormones, adrenocorticotropic hormone (ACTH) and corticosterone (Cort), and of three cytokines known as ACTH stimulators, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6, after intraarterial infusions of lipopolysaccharide (LPS) given at three doses, 5 mu g/kg (LPS-5), 25 mu g/kg (LPS-25), and 1 mg/kg (LPS-1,000). Blood samples were taken 30 min and immediately before LPS injection (t(0)) and at 15, 30, 60, 120, 300, and 480 min post-LPS. The three doses of LPS induced ACTH and Cort surges, starting after 30 min for LPS-5 and LPS-25 or 15 min for LPS-1,000 and peaking witha similar amplitude at 60 min before receding slowly to baseline at 480 min for the two lower LPS doses. On the other hand, whatever the LPS dose, none of the three cytokines rose above undetectable basal levels before 60 min. They increased thereafter to culminate 10- to 30-fold above baseline at 60 min (TNF-alpha) or 120 min (IL-1 beta and IL-6)after LPS and declined back to basal levels at 300 min (TNF-alpha, all doses, and IL-6 for LPS-5 and LPS-25). After LPS-25, only IL-1 beta had not regressed to baseline levels at 480 min. The data indicate that although none of the three cytokines at levels measurable in the systemic circulation may act as a direct trigger for the initial stage ofthe corticotropic stress response to LPS, they may nevertheless strongly contribute to the timing and amplitude of the ACTH and Cort peaks and in the hours-long sustained post-LPS activation of the corticotropic axis.

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Documento generato il 27/01/20 alle ore 13:58:11