Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THYMOPENTIN INCREASES THE SURVIVAL OF MICE AFTER ALLOGENEIC BLOOD-TRANSFUSION, BACTERIAL GAVAGE, AND BURN INJURY
Autore:
BRAGA M; DIFRANCESCO A; GIANOTTI L; VIGNALI A; COSTANTINI E; SOCCI C; FORTIS C; PAGANELLI G; DICARLO V;
Indirizzi:
UNIV MILAN,HOSP SAN RAFFAELE,INST SCI,IRCCS,DEPT SURG,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV MILAN,HOSP SAN RAFFAELE,INST SCI,ADOPT IMMUNOTHERAPY LAB I-20127MILAN ITALY UNIV MILAN,HOSP SAN RAFFAELE,INST SCI,DEPT NUCL MED MILAN ITALY
Titolo Testata:
The European journal of surgery
fascicolo: 6-7, volume: 160, anno: 1994,
pagine: 345 - 350
SICI:
1102-4151(1994)160:6-7<345:TITSOM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROBIAL TRANSLOCATION; IMMUNE FUNCTION; PROSTAGLANDIN-E2; MODEL;
Keywords:
BLOOD TRANSFUSION; BURN INJURY; THYMOPENTIN; BACTERIAL TRANSLOCATION; PROSTAGLANDIN E(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Braga et al., "THYMOPENTIN INCREASES THE SURVIVAL OF MICE AFTER ALLOGENEIC BLOOD-TRANSFUSION, BACTERIAL GAVAGE, AND BURN INJURY", The European journal of surgery, 160(6-7), 1994, pp. 345-350

Abstract

Objective: To investigate the effect of blood transfusion on mortality and the incidence of bacterial translocation in mice subjected to thermal burn or bacterial gavage, or both,and to assess the influence ofthymopentin on mortality. Design: Randomly controlled experiments. Setting: University departments of surgery, immunology and nuclear medicine. Material. 235 Balb/c (H-2(d)) and C3H/HeJ (H-2(k)) mice Interventions: 8 groups of 20 mice each received: saline infusion (controls), blood transfusion (BT) alone, 20% burn alone, gavage with 1x10(10) Escherichia coli alone, BT and gavage, BT and burn, burn and gavage, or BT, burn, and gavage. A further 3 groups of 10 mice were all gavaged with In-111-biotin labelled E coil and randomised to additional BT and burn, BT alone, or burn alone. 98 mice that had had BT, burn, and gavage, were then randomised to receive thymopentin 0, 0.1, 1, or 5 mg/kg/day for 15 days. The impact of the pretreatment with thymopentin on PGE(2) concentration was also evaluated in a separate group of 45 mice that received BT, burn, and gavage; or burn and gavage. Main outcome measures: Survival, degree of translocation. Results: The highest mortality (75%) was in the BT, burn, and gavage group. BT alone significantly reduced survival in burned mice, whereas BT alone or associated with gavage had no effect. Thermal injury had the most influence on bacterial translocation, whereas BT did not increase it. Thymopentin significantly improved survival, particularly in the higher doses. The pretreatment with thymopentin significantly reduced PGE(2) concentration afterBT, burn and gavage. Conclusion: Burn injury significantly increased mortality in the presence of immune deficiency caused by BT. Thymopentin reduced mortality, possibly by immunomodulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:12:07