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Titolo:
INCREASED RISK OF INFLAMMATORY BOWEL-DISEASE ASSOCIATED WITH ORAL-CONTRACEPTIVE USE
Autore:
BOYKO EJ; THEIS MK; VAUGHAN TL; NICOLBLADES B;
Indirizzi:
VET AFFAIRS MED CTR,MED SERV SEATTLE WA 98108 UNIV WASHINGTON,DEPT MED SEATTLE WA 00000 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104
Titolo Testata:
American journal of epidemiology
fascicolo: 3, volume: 140, anno: 1994,
pagine: 268 - 278
SICI:
0002-9262(1994)140:3<268:IROIBA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOWEL-DISEASE; CROHNS-DISEASE; THROMBOEMBOLIC DISEASE; CIGARETTE-SMOKING; UNITED-STATES; SELECTION; ESTROGEN; TRENDS;
Keywords:
CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; CONTRACEPTIVES, ORAL; CROHN DISEASE; INFLAMMATORY BOWEL DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Boyko et al., "INCREASED RISK OF INFLAMMATORY BOWEL-DISEASE ASSOCIATED WITH ORAL-CONTRACEPTIVE USE", American journal of epidemiology, 140(3), 1994, pp. 268-278

Abstract

Research on inflammatory bowel disease risk among oral contraceptive users has reached conflicting conclusions. This population-based case-control study evaluated the effects of oral contraceptive use on ulcerative colitis and Crohn's disease risk. Cases were women enrollees, aged 15-68 years, of Group Health Cooperative of Puget Sound (a prepaid health plan based in western Washington State) who had ulcerative colitis (n = 211) or Crohn's disease (n = 91). Age-matched controls were randomly selected from the health plan enrollment file. An in-person interview obtained information about lifetime contraceptive use. Conditional logistic regression analysis was used to estimate relative risks and 95% confidence intervals for disease. Women who reported oral contraceptive use within 6 months before disease onset were at increased risk for both diseases compared with never users (relative risk (RR) ofulcerative colitis = 2.0, 95% confidence interval (Cl) 1.2-3.3; RR ofCrohn's disease = 2.6, 95% CI 1.2-5.5). Women who had used oral contraceptives for more than 6 years had the highest risk of Crohn's disease (RR = 5.1, 95% CI 1.8-14.3). In contrast, increasing duration of usewas not associated with increased risk of ulcerative colitis. Adjustment for race, smoking, income, or pregnancy history did not substantially alter these results. Higher ulcerative colitis risk tended to occur among users of high estrogen dose oral contraceptives, while Crohn'sdisease risk was similar regardless of estrogen potency.

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Documento generato il 18/09/20 alle ore 20:08:46