Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ADVANCED GLYCATION END-PRODUCTS (AGES) ON THE SURFACE OF DIABETIC ERYTHROCYTES BIND TO THE VESSEL WALL VIA A SPECIFIC RECEPTOR INDUCING OXIDANT STRESS IN THE VASCULATURE - A LINK BETWEEN SURFACE-ASSOCIATED AGES AND DIABETIC COMPLICATIONS
Autore:
WAUTIER JL; WAUTIER MP; SCHMIDT AM; ANDERSON GM; HORI O; ZOUKOURIAN C; CAPRON L; CHAPPEY O; YAN SD; BRETT J; GUILLAUSSEAU PJ; STERN D;
Indirizzi:
HOP LARIBOISIERE,RECH BIOL VASC & CELLULARIE LAB,UNITE IMMUNOHEMATOL,2 RUE AMBROISE PARE F-75010 PARIS FRANCE HOP LARIBOISIERE,DEPT MED INTERNE PARIS FRANCE COLUMBIA UNIV,COLL PHYS & SURG,DEPT PHYSIOL NEW YORK NY 10032 HOP BROUSSAIS,CTR RECH MALADIES VASC PARIS FRANCE MERCK SHARP & DOHME LTD W POINT PA 19486
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 16, volume: 91, anno: 1994,
pagine: 7742 - 7746
SICI:
0027-8424(1994)91:16<7742:AGE(OT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED GLYCOSYLATION ENDPRODUCTS; HUMAN-ENDOTHELIAL CELLS; AUTOXIDATIVE GLYCOSYLATION; GLUCOSE; PROTEINS; IDENTIFICATION; GENERATION; PEROXIDES; DISEASE; CLONING;
Keywords:
VASCULAR COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Wautier et al., "ADVANCED GLYCATION END-PRODUCTS (AGES) ON THE SURFACE OF DIABETIC ERYTHROCYTES BIND TO THE VESSEL WALL VIA A SPECIFIC RECEPTOR INDUCING OXIDANT STRESS IN THE VASCULATURE - A LINK BETWEEN SURFACE-ASSOCIATED AGES AND DIABETIC COMPLICATIONS", Proceedings of the National Academy of Sciences of the United Statesof America, 91(16), 1994, pp. 7742-7746

Abstract

Vascular complications are an important cause of morbidity and mortality in patients with diabetes. The extent of vascular complications has been linked statistically to enhanced adherence of diabetic erythrocytes to endothelial cells (ECs) and to the accumulation of a class of glycated proteins termed advanced glycation end products (AGEs). We hypothesized that formation of AGEs on the surface of diabetic erythrocytes could mediate their interaction with ECs leading to binding and induction of vascular dysfunction. Enhanced binding of diabetic erythrocytes to ECs was blocked by preincubation of erythrocytes with anti-AGEIgG or preincubation of ECs with antibodies to the receptor for AGE (RAGE). Immunoblotting of cultured human ECs and immunostaining of normal/diabetic human tissue confirmed the presence of RAGE is the vessel wall. Binding of diabetic erythrocytes to endothelium generated an oxidant stress, as measured by production of thiobarbituric acid-reactivesubstances (TEARS) and activation of the transcription factor NF-kappa B, both of which were blocked by probucol or anti-RAGE IgG. Erythrocytes from diabetic rats infused into normal rats had an accelerated, early phase of clearance that was prevented, in part, by antibody to RAGE. Liver tissue from rats infused with diabetic erythrocytes showed elevated levels of TBARS, which was prevented by pretreatment with anti-RAGE IgG or probucol. Thus, erythrocyte surface AGEs can function as ligands that interact with RAGE on endothelium. The extensive contact of diabetic erythrocytes bearing surface-associated AGEs with vessel wall RAGE could be important in the development of vascular complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 13:26:00