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Titolo:
PHENOMENOLOGICAL COMPARISON OF THE IDIOPATHIC PSYCHOSIS OF SCHIZOPHRENIA AND DRUG-INDUCED COCAINE AND PHENCYCLIDINE PSYCHOSES - A RETROSPECTIVE STUDY
Autore:
ROSSE RB; COLLINS JP; FAYMCCARTHY M; ALIM TN; WYATT RJ; DEUTSCH SI;
Indirizzi:
VET AFFAIRS MED CTR,PSYCHIAT SERV,50 IRVING ST NW,RM 3A154-116A WASHINGTON DC 20422 VET AFFAIRS MED CTR,PSYCHIAT SERV WASHINGTON DC 20422 GEORGETOWN UNIV,SCH MED,DEPT PSYCHIAT WASHINGTON DC 00000 HOWARD UNIV,CTR MED,DEPT PSYCHIAT WASHINGTON DC 00000 ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,NEUROPSYCHIAT BRANCH WASHINGTON DC 20032
Titolo Testata:
Clinical neuropharmacology
fascicolo: 4, volume: 17, anno: 1994,
pagine: 359 - 369
SICI:
0362-5664(1994)17:4<359:PCOTIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PARANOIA; SYMPTOMS; MODEL;
Keywords:
COCAINE; PHENCYCLIDINE; SCHIZOPHRENIA; PSYCHOSIS; PHENOMENOLOGY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Rosse et al., "PHENOMENOLOGICAL COMPARISON OF THE IDIOPATHIC PSYCHOSIS OF SCHIZOPHRENIA AND DRUG-INDUCED COCAINE AND PHENCYCLIDINE PSYCHOSES - A RETROSPECTIVE STUDY", Clinical neuropharmacology, 17(4), 1994, pp. 359-369

Abstract

Both stimulant-induced and phencyclidine (PCP)-induced psychoses havebeen proposed as models of the idiopathic psychosis of schizophrenia. In this two-part study, the phenomenology of the psychosis associatedwith a period of cocaine intoxication was evaluated retrospectively in 34 male crack cocaine-dependent patients without concomitant psychiatric disorder and then was compared with the psychosis of 16 actively psychotic schizophrenic men (without a history of drug or alcohol abuse in the past year). Certain First Rank Schneiderian Symptoms (FRSS) were more commonly observed in the schizophrenic patients (e.g., thought broadcasting, thought withdrawal) than in the cocaine addicts. In the second part of this study, we retrospectively examined the cocaine and PCP experiences of an additional 22 cocaine addicts who had a past history of separate periods of cocaine and PCP use. Overall, the frequency of FRSS recalled during periods of cocaine and PCP intoxication was similar. However, the psychosis related to cocaine intoxication wasmore associated with an intense suspiciousness and paranoia related to a fear of being discovered or harmed while using cocaine. PCP-induced psychosis was less associated with suspiciousness and more associated with delusions of physical power, altered sensations, and unusual experiences [e.g., out of body experiences, experiencing religious figures or events directly (e.g., being with Noah at the time of the Arc)]. As elements of both cocaine and PCP psychosis can be found in schizophrenia, a model integrating the mechanisms of several psychotogenic drugs may be more informative. Such an integrative model might better capture the heterogeneity of psychotic symptoms that can be seen in schizophrenia. Furthermore, different pharmacologic interventions (e.g., ''anti-stimulant'' versus ''anti-PCP'') might address different aspectsof the positive symptom picture in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:45:16