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Titolo:
CHARACTERIZATION OF 2 FORMS OF PEPTIDE-YY, PYY(1-36) AND PYY(3-36), IN THE RABBIT
Autore:
GRANDT D; SCHIMICZEK M; STRUK K; SHIVELY J; EYSSELEIN VE; GOEBELL H; REEVE JR;
Indirizzi:
UNIV ESSEN GESAMTHSCH KLINIKUM,GASTROENTEROL ABT,MED KLIN,HUFELANDSTR55 D-45122 ESSEN GERMANY CITY HOPE RES INST,DIV IMMUNOL DUARTE CA 91010 UNIV CALIF LOS ANGELES,HARBOR MED CTR,DEPT GASTROENTEROL TORRANCE CA 90509 UNIV CALIF LOS ANGELES,VET ADM WADSWORTH MED CTR,DEPT MED,CTR ULCER RES & EDUC LOS ANGELES CA 90073
Titolo Testata:
Peptides
fascicolo: 5, volume: 15, anno: 1994,
pagine: 815 - 820
SICI:
0196-9781(1994)15:5<815:CO2FOP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; NEUROGENIC VASOCONSTRICTION; STRUCTURAL CHARACTERIZATION; PANCREATIC-POLYPEPTIDE; ION-TRANSPORT; PYY; INHIBITION; SECRETION; RAT; RELEASE;
Keywords:
PEPTIDE YY; GASTROINTESTINAL HORMONES; RECEPTOR; RECEPTOR HETEROGENEITY; MOLECULAR HETEROGENEITY; RABBIT; HPLC; RADIOIMMUNOASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D. Grandt et al., "CHARACTERIZATION OF 2 FORMS OF PEPTIDE-YY, PYY(1-36) AND PYY(3-36), IN THE RABBIT", Peptides, 15(5), 1994, pp. 815-820

Abstract

Peptide YY (PYY) has been purified as a 36 amino acid peptide from intestinal extracts of several mammalian species including pig, rat, dog, and man. The primary structure of rabbit PYY is still unknown, although rabbit tissues have extensively been used for characterization of PYY receptor subtypes and receptor subtype-mediated actions. We reportthe purification and primary structure of PYY(1-36)(PYY-I) from rabbit intestinal mucosa, and the existence of a second endogenous molecular form of PYY, PYY(3-36)(PYY-II). The amino acid sequence of PYY-I is YPSKPEAPGEDASPEELNRYYASLRHYLNLVTROQRY-amide. Rabbit PYY differs from porcine PYY, which is identical to rat and canine PYY, by two amino acid substitutions at positions 3 (Ser instead of Ala) and 18 (Asp instead of Ser), whereas rabbit PYY and human PYY differ by only one residueat position 3 (Ser instead of Ile). The existence of two endogenous forms of PYY in the rabbit, with PYY-II lacking the amino-terminal dipeptide Tyr-Pro of PYY-I, is consistent with previously reported findings, demonstrating the existence of PYY-II in man and dog (9,11). We have previously demonstrated that PYY-I is an unselective Y-1/Y-2 agonist, whereas PYY-II is a highly selective Y-2 agonist. Thus, proteolytic processing of PYY-I controls the peptides receptor selectivity. The existence of PYY-I and PYY-II in the rabbit supports the assumption of aphysiological role of Y receptor heterogeneity for PYY.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:11:41