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Titolo:
BETA-ENDORPHIN CONTENT IN HIV-INFECTED HUT78 CELL-LINE AND IN PERIPHERAL LYMPHOCYTES FROM HIV-POSITIVE SUBJECTS
Autore:
BARCELLINI W; SACERDOTE P; BORGHI MO; RIZZARDI GP; FAIN C; MORGHEN CD; MANFREDI B; LAZZARIN A; MERONI PL; PANERAI AE; ZANUSSI C;
Indirizzi:
OSPED POLICLIN,INST INTERNAL MED,PAD GRANELLI,VIA F SFORZA 35 I-20122MILAN ITALY UNIV MILAN,INST INTERNAL MED INFECT DIS & IMMUNOPATHOL MILAN ITALY UNIV MILAN,DEPT PHARMACOL MILAN ITALY
Titolo Testata:
Peptides
fascicolo: 5, volume: 15, anno: 1994,
pagine: 769 - 775
SICI:
0196-9781(1994)15:5<769:BCIHHC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; MONONUCLEAR-CELLS; DRUG-USERS; MODULATION; AIDS; NEUROPEPTIDES; CORTICOTROPIN; BRAIN; RATS;
Keywords:
BETA-ENDORPHIN; HIV INFECTION; OPIOIDS; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
W. Barcellini et al., "BETA-ENDORPHIN CONTENT IN HIV-INFECTED HUT78 CELL-LINE AND IN PERIPHERAL LYMPHOCYTES FROM HIV-POSITIVE SUBJECTS", Peptides, 15(5), 1994, pp. 769-775

Abstract

We investigated beta-endorphin (BE) content in an HIV-infected cell line and in peripheral blood mononuclear cells (PBM) from HIV-positive subjects. HIV infection increased BE content in HuT78 cell line compared to uninfected cells. Accordingly, BE content was greater in HIV-positive subjects than in healthy controls, both in fresh PBM and in mitogen-stimulated or unstimulated cultured cells. Further, in PHA-stimulated cultures, BE increase was correlated with disease progression. Opioids are known to decrease immune responsiveness in vivo, and it may be that the increased BE concentrations contribute to HIV-associated immune deficiency. In HIV-positive subjects, but not in healthy controls, intracellular BE concentration was positively correlated with PHA-induced PBM proliferation. The latter data suggest an alternative explanation: that the increased BE content represents a paradoxical responseof the host in an attempt to balance virus-induced immunodepression. Thus, BE may be important in fine-tuning of the immune response with its up- and downregulation dependent upon differences in immune status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:59:16