Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SPET INVESTIGATIONS IN EXTRAPYRAMIDAL DISEASES USING SPECIFIC LIGANDS
Autore:
STAFFEN W; HONDL N; TRINKA E; ZENZMAIER R; LADURNER G;
Indirizzi:
IGNAZ HARRER STR 79 A-5020 SALZBURG AUSTRIA LANDESNERVENKLIN SALZBURG,DEPT NEUROL SALZBURG AUSTRIA
Titolo Testata:
Nuclear medicine communications
fascicolo: 2, volume: 18, anno: 1997,
pagine: 159 - 163
SICI:
0143-3636(1997)18:2<159:SIIEDU>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; I-123 IBZM-SPECT; DOPAMINE-RECEPTOR; HUNTINGTONS-DISEASE; INVITRO BINDING; WILSONS-DISEASE; UPTAKE SITES; BETA-CIT; TRANSPORTERS; RADIOPHARMACEUTICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
W. Staffen et al., "SPET INVESTIGATIONS IN EXTRAPYRAMIDAL DISEASES USING SPECIFIC LIGANDS", Nuclear medicine communications, 18(2), 1997, pp. 159-163

Abstract

Single photon emission tomographic investigations of the extrapyramidal system have become easier to perform since the development of the ligands [I-123]-beta-CIT and [I-123]-IBZM. Thirty-three patients were investigated with [I-123]-IBZM. The images were evaluated visually and semi-quantitatively (ratio of the striatum to front cortex). Ten controls showed a mean (+/-S.D.) ratio of 1.513 +/- 0.06; nine patients with Parkinson's disease had a smaller ratio of 1.425 +/- 0.095; six patients with Huntington's disease had a significantly lower ratio (1.147 /- 0.105). Eight patients were not classified, because of different nosologic entities. Twenty-three patients were investigated with [I-123]-beta-CIT. They were evaluated using standard techniques and the ratio of the striatum to cerebellum. Six controls had a mean ratio of 5.128 +/- 0.787. In 11 Parkinson patients, the ratio was significantly less (3.359 +/- 0.769). Patients with focal dystonia showed normal values. One patient with Huntington's disease had a significantly lower ratio. Receptor studies of the extrapyramidal system may help with diagnoses and could be of relevance therapeutically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 14:36:59