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Titolo:
EXCIMER-LASER ABLATION OF SOFT-TISSUE - A STUDY OF THE CONTENT OF RAPIDLY EXPANDING AND COLLAPSING BUBBLES
Autore:
VANLEEUWEN TG; JANSEN ED; MOTAMEDI M; WELCH AJ; BORST C;
Indirizzi:
UNIV UTRECHT HOSP,EXPTL CARDIOL LAB 3511 GV UTRECHT NETHERLANDS INTERUNIV CARDIOL INST NETHERLANDS UTRECHT NETHERLANDS UNIV TEXAS,BIOMED ENGN PROGRAM AUSTIN TX 78712 UNIV TEXAS,MED BRANCH,CTR BIOMED ENGN,BIOMED OPT LAB,BIOMED LASER & SPECT PROGRAM GALVESTON TX 77550 UNIV UTRECHT HOSP,INST HEART LUNG,DEPT CARDIOL 3511 GV UTRECHT NETHERLANDS
Titolo Testata:
IEEE journal of quantum electronics
fascicolo: 5, volume: 30, anno: 1994,
pagine: 1339 - 1347
SICI:
0018-9197(1994)30:5<1339:EAOS-A>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY ANGIOPLASTY; ARTERIAL-WALL; FIBER; WAVELENGTH; PLAQUE; DAMAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T.G. Vanleeuwen et al., "EXCIMER-LASER ABLATION OF SOFT-TISSUE - A STUDY OF THE CONTENT OF RAPIDLY EXPANDING AND COLLAPSING BUBBLES", IEEE journal of quantum electronics, 30(5), 1994, pp. 1339-1347

Abstract

Both holmium (lambda = 2.09 mum) and excimer (lambda = 308 nm) lasersare used for ablation of tissue. In a previous study, excimer laser ablation of aorta produced rapidly expanding and collapsing vapor bubbles. To investigate whether the excimer-induced bubble is caused by vaporization of (tissue) water, the threshold fluence for bubble formation at a bare fiber tip in water and on tissue was compared between the excimer laser (pulse length 115 ns) and the Q-switched and free-running holmium lasers (pulse length 1 mus and 250 mus, respectively). To induce bubble formation by excimer laser light in water, the absorber Oxybuprocaine-hydrochloride (OBP-HCl) was added to the water. Fast flashphotography was used to measure the threshold fluence as a function of the water temperature (6-90-degrees-C) at ambient pressure and as a function of the boiling temperature of water (100-184-degrees-C) at augmented environmental pressures (1-11 bar). For both the holmium and excimer laser, the threshold fluence for bubble formation decreased proportionally with increasing water temperature (correlation coefficientr = 0.95-0.99). Correspondingly, the threshold fluence for bubble formation increased with increasing boiling temperature of water. A similar correlation was found for the excimer laser-induced bubble formation on tissue. Furthermore, for both the holmium and the excimer laser, the threshold fluence for water vaporization was much lower than theoretically predicted values. We conclude that the principal content of the large (up to 3 mm), short lived (<300 mus) bubble induced by a 308 nm excimer laser pulse is tissue water vapor, rather than a mixture ofcompounds generated by pyrolysis of tissue proteins. Consequently, explosive vaporization of tissue water may contribute to the excimer laser ablation of aortic tissue.

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Documento generato il 02/12/20 alle ore 15:17:55