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Titolo:
NITRIC-OXIDE - A NOVEL AUTONOMIC NEUROTRANSMITTER
Autore:
GROZDANOVIC Z; BRUNING G; BAUMGARTEN HG;
Indirizzi:
FREE UNIV BERLIN,INST ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY
Titolo Testata:
Acta anatomica
fascicolo: 1, volume: 150, anno: 1994,
pagine: 16 - 24
SICI:
0001-5180(1994)150:1<16:N-ANAN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER ESOPHAGEAL SPHINCTER; NONADRENERGIC NONCHOLINERGIC NERVES; CYCLIC-NUCLEOTIDE CONTENT; NADPH-DIAPHORASE ACTIVITY; GUINEA-PIG HEART; VASOACTIVE-INTESTINAL-PEPTIDE; RAT ANOCOCCYGEUS MUSCLE; CANINE PROXIMAL COLON; NERVOUS-SYSTEM; SMOOTH-MUSCLE;
Keywords:
AUTONOMIC NERVOUS SYSTEM; NADPH-DIAPHORASE; NEUROTRANSMISSION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
Z. Grozdanovic et al., "NITRIC-OXIDE - A NOVEL AUTONOMIC NEUROTRANSMITTER", Acta anatomica, 150(1), 1994, pp. 16-24

Abstract

Considerable evidence suggests that nitric oxide (NO) acts as a nonadrenergic noncholinergic (NANC) transmitter at autonomic neuroeffector junctions. NO is generated enzymatically from L-arginine by a constitutive, cytosolic, Ca2(+)/calmodulin-activated NO synthase (NOS): NADPH-and tetrahydrobiopterin-dependent cytochrome P-450-type hemoprotein. Electrophysiological and pharmacological data indicate that NO fulfilsmost of the criteria for a neurotransmitter. It is released from axonterminals when invaded by action potentials and mimics the effect of nerve stimulation. The changes in the mechanical and/or electrical activity of smooth muscle preparations in response to transmural stimulation of NANC nerves are antagonized by inhibitors of NO synthesis or oxyhemoglobin, an NO scavenger. NO acts principally by stimulating soluble guanylate cyclase. Studies on the histochemical localization of NOSpoint to the involvement of the neural L-arginine-NO pathway in the regulation of vascular tone and of several aspects of respiratory, gastrointestinal, and genitourinary tract functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:21:34