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Titolo:
ACTIVATION OF AN INFLUENZA-VIRUS A TURKEY/OREGON/71 HA INSERTION VARIANT BY THE SUBTILISIN-LIKE ENDOPROTEASE FURIN/
Autore:
MORSY J; GARTEN W; ROTT R;
Indirizzi:
UNIV GIESSEN,INST VIROL,FRANKFURTER STR 107 D-35392 GIESSEN GERMANY UNIV GIESSEN,INST VIROL D-35392 GIESSEN GERMANY UNIV MARBURG,INST VIROL W-3550 MARBURG GERMANY
Titolo Testata:
Virology
fascicolo: 2, volume: 202, anno: 1994,
pagine: 988 - 991
SICI:
0042-6822(1994)202:2<988:AOAIAT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLEAVAGE ACTIVATION; HEMAGGLUTININ; SEQUENCE; INHIBITION; CELLS; SITE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J. Morsy et al., "ACTIVATION OF AN INFLUENZA-VIRUS A TURKEY/OREGON/71 HA INSERTION VARIANT BY THE SUBTILISIN-LIKE ENDOPROTEASE FURIN/", Virology, 202(2), 1994, pp. 988-991

Abstract

The hemagglutinin (HA) gene of the influenza A turkey/Oregon/71 variant Tc1 adapted to primary chicken embryo cells contains an insertion of 54 nucleotides that encodes a peptide adjacent to the HA cleavage site, which is responsible for increased cleavability by ubiquitous cellular proteases. After coexpression with human furin from cDNA by vaccinia virus vectors and by an endogenous protease, the HA of Tc1, which possesses the amino acid sequence R-T-A-R at the cleavage site, is proteolytically processed. Site-directed mutagenesis of the cleavage siteindicated that the arginine in position -4 is critical for HA activation by furin. Deletion of the insert revealed that the amino acid sequence -1 to -4 predisposes the protein for furin recognition. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:47:34