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Titolo:
INTRATHECAL PRODUCTION OF INTERLEUKIN-12 AND GAMMA-INTERFERON IN PATIENTS WITH BACTERIAL-MENINGITIS
Autore:
KORNELISSE RF; HACK CE; SAVELKOUL HFJ; RAAN TCTMV; HOP WCJ; VANMIERLO G; SUUR MH; NEIJENS HJ; DEGROOT R;
Indirizzi:
SOPHIA CHILDRENS UNIV HOSP,DEPT PEDIAT,DIV PEDIAT INFECT DIS & IMMUNOL,DR MOLEWATERPLEIN 60 NL-3015 GJ ROTTERDAM NETHERLANDS SOPHIA CHILDRENS UNIV HOSP,DEPT PEDIAT,DIV PEDIAT INFECT DIS & IMMUNOL NL-3015 GJ ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT IMMUNOL NL-3015 GJ ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT EPIDEMIOL & BIOSTAT NL-3015 GJ ROTTERDAM NETHERLANDS UNIV AMSTERDAM,NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT AUTOIMMUNE DIS INFLAMMAT NL-1066 CX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,CLIN & EXPT IMMUNOL LAB NL-1066 CX AMSTERDAM NETHERLANDS
Titolo Testata:
Infection and immunity
fascicolo: 3, volume: 65, anno: 1997,
pagine: 877 - 881
SICI:
0019-9567(1997)65:3<877:IPOIAG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; T RESPONSES INVITRO; CEREBROSPINAL-FLUID; FACTOR-ALPHA; NK-CELLS; RECOMBINANT INTERLEUKIN-2; SCID MICE; IL-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Kornelisse et al., "INTRATHECAL PRODUCTION OF INTERLEUKIN-12 AND GAMMA-INTERFERON IN PATIENTS WITH BACTERIAL-MENINGITIS", Infection and immunity, 65(3), 1997, pp. 877-881

Abstract

To assess the role of interleukin-12 (IL-12) and gamma interferon (IFN-gamma) in children with bacterial meningitis, bioactive IL-12 (p70) and the inactive subunit p40 and IFN-gamma were measured in serum and cerebrospinal fluid (CSF) from 35 children with bacterial meningitis and 10 control subjects, The production of IFN-gamma is induced by IL-12 with tumor necrosis factor alpha (TNF-alpha) as a costimulator and inhibited by IL-10, CSF concentrations of IL-12 p40 as well as those ofIFN-gamma were markedly elevated, whereas IL-12 p70 was hardly detectable, Detectable CSF levels of IFN-gamma correlated positively with IL-12 p40 (r = 0.40, P = 0.02) and TNF-alpha (r = 0.46, P = 0.04) but not with IL-6, IL-8, or IL-10, In contrast to CSF levels of TNF-alpha, IL-12, and IL-10, those of IFN-gamma were significantly higher in patients with pneumococcal meningitis than in children with meningitis caused by Haemophilus influenzae and Neisseria meningitidis, presumably because of a high CSF TNF-alpha/IL-10 ratio in the former, We suggest that IL-12- and TNF-alpha-induced IFN-gamma production may contribute tothe natural immunity against microorganisms in the CSF compartment during the acute phase of bacterial meningitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 12:55:45