Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROGESTERONE STIMULATES GNRH GENE-EXPRESSION IN THE HYPOTHALAMUS OF OVARIECTOMIZED, ESTROGEN-TREATED ADULT-RATS
Autore:
CHO BN; SEONG JY; CHO H; KIM K;
Indirizzi:
SEOUL NATL UNIV,COLL NAT SCI,DEPT MOLEC BIOL SEOUL 150742 SOUTH KOREA SEOUL NATL UNIV,COLL NAT SCI,DEPT MOLEC BIOL SEOUL 150742 SOUTH KOREA SEOUL NATL UNIV,COLL NAT SCI,SRC CELL DIFFERENTIAT SEOUL 150742 SOUTHKOREA
Titolo Testata:
Brain research
fascicolo: 1, volume: 652, anno: 1994,
pagine: 177 - 180
SICI:
0006-8993(1994)652:1<177:PSGGIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; LHRH MESSENGER-RNA; LUTEINIZING-HORMONE; INSITU HYBRIDIZATION; NEURONS; BRAIN; PITUITARY;
Keywords:
PROGESTERONE; RU486; GONADOTROPIN-RELEASING HORMONE MESSENGER-RNA; HYPOTHALAMUS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
B.N. Cho et al., "PROGESTERONE STIMULATES GNRH GENE-EXPRESSION IN THE HYPOTHALAMUS OF OVARIECTOMIZED, ESTROGEN-TREATED ADULT-RATS", Brain research, 652(1), 1994, pp. 177-180

Abstract

Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect releaseand content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatoryaction of P on GnRH mRNA level. These results strongly suggest that Pregulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:46:26