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Titolo:
BCL-2 PROTOONCOGENE AND EPSTEIN-BARR-VIRUS LATENT MEMBRANE PROTEIN-1 EXPRESSION IN AIDS-RELATED LYMPHOMA
Autore:
SCHLAIFER D; BROUSSET P; ATTAL M; MASSIP P; PAYEN C; MARCHOU B; HUGUET F; MULLER C; LAURENT G; PRIS J; DELSOL G;
Indirizzi:
HOP PURPAN,CTR HOSP REG,DEPT HAEMATOL,SERV HEMATOL,DIEULAFOY CLIN,PL DOCTEUR BAYLAC F-31059 TOULOUSE FRANCE HOP PURPAN,DEPT PATHOL TOULOUSE FRANCE HOP PURPAN,DEPT INFECT DIS TOULOUSE FRANCE
Titolo Testata:
Histopathology
fascicolo: 1, volume: 25, anno: 1994,
pagine: 77 - 82
SICI:
0309-0167(1994)25:1<77:BPAELM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; NON-HODGKINS-LYMPHOMA; NASOPHARYNGEAL CARCINOMA; INSITU HYBRIDIZATION; CELL-DEATH; DISEASE; TRANSLOCATION; ASSOCIATION; NEOPLASMS; INDUCTION;
Keywords:
AIDS; LYMPHOMA; EPSTEIN-BARR VIRUS; BCL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D. Schlaifer et al., "BCL-2 PROTOONCOGENE AND EPSTEIN-BARR-VIRUS LATENT MEMBRANE PROTEIN-1 EXPRESSION IN AIDS-RELATED LYMPHOMA", Histopathology, 25(1), 1994, pp. 77-82

Abstract

The expression of bcl-2 protein and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) was investigated in 18 cases of lymphoma occurring in the acquired immunodeficiency syndrome (AIDS). EBV small RNAs were detectable in tumour cells in all cases by in situ hybridization with EBER oligonucleotides. LMP-1 expression was detected in 61% of the cases, and 55% were positive for bcl-2. Dual expression of LMP-1 and bcl-2 was found in 8/18 (44%) cases, while five cases (28%) expressed either LMP-1 or bcl-2 and five expressed neither. Thus, there was an inconsistent relationship between the presence of EBV and the expression of bcl-2. One LMP-1 negative case was found to express bcl-2 in reactive lymphocytes but not in lymphoma cells. No clinical features were found to correlate statistically with LMP-1 or bcl-2 expression in the tumour cells. However, CD4 counts at diagnosis were significantly lower in bcl-2 positive cases (P < 0.05). The respective roles of EBV LMP-1 and the expression of bcl-2 in lymphogenesis in AIDS patients remains complex and is not yet fully understood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:43:50