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Titolo:
ROLE OF VAGAL AFFERENTS IN HYPOTENSION INDUCED BY VENOUS AIR-EMBOLISM
Autore:
AIBIKI M; OGURA S; SEKI K; HONDA K; UMEGAKI O; SHIRAKAWA Y; OGLI K;
Indirizzi:
KAGAWA MED SCH,DEPT ANESTHESIOL & EMERGENCY MED,KITA KU,1750-1 IKENOBE KAGAWA 76107 JAPAN
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 266, anno: 1994,
parte:, 2
pagine: 180000790 - 180000795
SICI:
0002-9513(1994)266:3<180000790:ROVAIH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE;
Keywords:
ARTERIAL BARORECEPTORS; BARORECEPTOR SENSITIVITY; CARDIOPULMONARY BARORECEPTORS; CENTRAL VENOUS PRESSURE; SYMPATHETIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Aibiki et al., "ROLE OF VAGAL AFFERENTS IN HYPOTENSION INDUCED BY VENOUS AIR-EMBOLISM", The American journal of physiology, 266(3), 1994, pp. 180000790-180000795

Abstract

To evaluate the role of the autonomic nervous system in the development of hypotension during air embolism, we studied the effects of an intravenous bolus injection of air (0.5 ml/kg) on mean blood pressure (MBP), central venous pressure (CVP), and renal nerve activity (RNA) in urethan-anesthetized rabbits of three groups: animals with an intact neuraxis (intact group; n = 5), cervical-vagotomized animals (vagotomy group; n = 5), and sinoaortic-denervated animals (SAD group; n = 5). In the intact group, despite a significant decrease in MBP at 10 s after air injection, RNA did not increase from the preinjection level. This response of RNA was associated with a significant increase in CVP and lasted for 20 s after the injection. Vagotomized animals, however, exhibited a significant augmentation in RNA in response to a drop in MBP at 10 s after the injection. In the SAD group, profound declines in both MBP and RNA were observed at 10 s after the injection of air. Animals in these two groups showed remarkable increases in CVP. At 5 min after the air administration, MBP in the vagotomy group was significantly higher than that in the intact group. Ah animals in the SAD group died within 5 min of the injection. These results indicate that duringhypotension induced by air injection, sympathetic activation through arterial baroreceptors may be depressed by vagal afferents emanating from cardiopulmonary receptors; the results also suggest that the arterial baroreceptor nerves may be required to overcome the lethal events that should occur during venous air embolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:07:40