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Titolo:
RENIN AND VASOPRESSIN RESPONSES TO GRADED REDUCTIONS IN ATRIAL PRESSURE IN CONSCIOUS DOGS
Autore:
ODONNELL CP; THOMPSON CJ; KEIL LC; THRASHER TN;
Indirizzi:
UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHYSIOL,BOX 0444 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHYSIOL SAN FRANCISCO CA 94143 NASA,AMES RES CTR MOFFETT FIELD CA 94035
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 266, anno: 1994,
parte:, 2
pagine: 180000714 - 180000721
SICI:
0002-9513(1994)266:3<180000714:RAVRTG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BARORECEPTORS; PLASMA VASOPRESSIN; CARDIAC RECEPTORS; ANESTHETIZED DOGS; HEMORRHAGE; SECRETION; BLOCKADE; RELEASE;
Keywords:
ARTERIAL BARORECEPTORS; CAROTID SINUS RECEPTORS; CARDIAC RECEPTORS; PLASMA RENIN ACTIVITY; ARGININE VASOPRESSIN; ANTIDIURETIC HORMONE; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Odonnell et al., "RENIN AND VASOPRESSIN RESPONSES TO GRADED REDUCTIONS IN ATRIAL PRESSURE IN CONSCIOUS DOGS", The American journal of physiology, 266(3), 1994, pp. 180000714-180000721

Abstract

Hypovolemia activates reflexes that stimulate secretion of renin and arginine vasopressin (AVP). A large body of evidence, obtained mainly in anesthetized preparations, supports the hypothesis that unloading cardiac receptors stimulates increases in plasma AVP and renin activity(PRA). We have observed significant increases in PRA before any change in either mean arterial pressure (MAP) or pulse pressure in conscious dogs undergoing continuous hemorrhage; however, plasma AVP did not change until there was a significant fall in MAP. These results are compatible with the hypothesis that cardiac receptors cause reflex stimulation of renin but not AVP secretion. The aim of the present study wasto test the hypothesis that a decrease in atrial pressure alone is sufficient to stimulate an increase in plasma AVP and PRA. Graded thoracic inferior vena caval constriction (TTVCC) was used to reduce atrial pressure in four steps without altering MAP in conscious dogs. In a fifth step, TIVCC was increased to cause a fall in MAP. A reduction in left atrial pressure (LAP) of 4.2 +/- 0.9 mmHg was accompanied by a significant (P < 0.05) increase in PRA from a control value of 0.4 +/- 0.1 ng angiotensin I (ANG I).ml(-1).3 h(-1) to 1.1 +/- 0.2 ng ANG I.ml(-1).3 h(-1) but no change in plasma AVP (from 1.0 +/- 0.1 to 1.2 +/- 0.2 pg/ml) or MAP (from 85 +/- 5 mmHg to 86 +/- 4 mmHg). Reducing LAP by7.5 +/- 1.0 mmHg below control stimulated a further increase in PRA (1.8 +/- 0.5 ng ANG I.ml(-l).3 h(-1)) but no change in plasma AVP (3.7 /- 1.7 pg/ml) or MAP (84 +/- 4 mmHg). Increasing TIVCC enough to cause a fall in MAP (25 +/- 4 mmHg below control) was accompanied by a significant increase in plasma AVP (20 +/- 3 pg/ml above control). These results demonstrate that unloading cardiac receptors alone is sufficient to stimulate an increase in renin but not AVP secretion in conscious dogs. The results suggest that arterial pressure is the critical variable in the AVP response to acute hypovolemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:14:16