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Titolo:
GASTROINTESTINAL HEMODYNAMICS DURING COMPENSATION FOR HEMORRHAGE AND MEASUREMENT OF PMCF
Autore:
ROTHE CF; MAASSMORENO R;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS MED SCI 374,635 BARNHILL DR INDIANAPOLIS IN 46202
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 266, anno: 1994,
parte:, 2
pagine: 80001242 - 80001250
SICI:
0002-9513(1994)266:3<80001242:GHDCFH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATORY FILLING PRESSURE; SINUS BARORECEPTOR REFLEX; SYSTEMIC VASCULAR BED; HEPATIC CAPACITANCE RESPONSES; BLOOD-VOLUME; ENDOTOXIN-SHOCK; DOGS; FLOW; RESISTANCE; INDICATOR;
Keywords:
MEAN CIRCULATORY FILLING PRESSURE; GASTROINTESTINAL VASCULATURE; VASCULAR COMPLIANCE; VASCULAR RESISTANCE; VENOUS RESISTANCE; BLOOD VOLUME; TRANSFUSION; INDOCYANINE GREEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Rothe e R. Maassmoreno, "GASTROINTESTINAL HEMODYNAMICS DURING COMPENSATION FOR HEMORRHAGE AND MEASUREMENT OF PMCF", The American journal of physiology, 266(3), 1994, pp. 80001242-80001250

Abstract

To quantify the degree of autonomic reflex control of the gastrointestinal vasculature, we studied the responses to a 10-ml/kg hemorrhage or transfusion and autonomic blockade in fentanyl- and pentobarbital-anesthetized dogs. The active total blood volume was estimated by indocyanine green dilution. Transfusion and hemorrhage did not significantlychange gastrointestinal vascular compliance [1.82 +/- 0.68 (SD) ml/mmHg], but autonomic blockade with hexamethonium and atropine increased it by 0.57 +/- 0.37 ml/mmHg. Neither hemorrhage nor autonomic blockadesignificantly changed gastrointestinal vascular resistance from its control value of 10.8 +/- 4 mmHg.ml(-1).min.kg body wt, but transfusionreduced it by 3.0 +/- 1.2 mmHg.ml(-1).min.kg body wt. The ratio of gastrointestinal vascular resistance to total peripheral resistance was not significantly changed, however. We conclude that vascular compliance and resistance of the gastrointestinal bed are minimally influencedby the autonomic nervous system under the conditions studied. Portal pressure and flow measurements (transit-time ultrasound) during the above maneuvers were also combined with estimations of mean circulatory filling pressure (Pmcf) to test the hypothesis that, when the heart isstopped to measure Pmcf, portal pressure equals central venous pressure (Pcv) and hence that portal flow is zero. Seven seconds after the heart was stopped, portal venous pressure (Ppv) remained 0.83 +/- 0.78 mmHg higher than Pcv and portal flow decreased to only 25% of its control value. However, gastrointestinal compliance times (Ppv - Pcv), an estimate of the extra distending volume, was only 0.07 +/- 0.07 ml/kg body wt. Thus we conclude that the error in estimating Pmcf, given this (Ppv - Pcv) difference, is physiologically insignificant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:35:58