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Titolo:
TUMOR-NECROSIS-FACTOR-ALPHA ENHANCES THE EXPRESSION OF THE INTERLEUKIN (IL)-4 RECEPTOR ALPHA-CHAIN ON ENDOTHELIAL-CELLS INCREASING IL-4 OR IL-13-INDUCED STAT6 ACTIVATION
Autore:
LUGLI SM; FENG NP; HEIM MH; ADAM M; SCHNYDER B; ETTER H; YAMAGE M; EUGSTER HP; LUTZ RA; ZURAWSKI G; MOSER R;
Indirizzi:
ETH ZURICH,INST TOXICOL,SCHORENSTR 16 CH-8603 SCHWERZENBACH SWITZERLAND SWISS FED INST TECHNOL,INST TOXICOL CH-8057 ZURICH SWITZERLAND UNIV ZURICH HOSP,INST CLIN CHEM CH-8091 ZURICH SWITZERLAND UNIV BASEL HOSP,DEPT RES CH-4031 BASEL SWITZERLAND DUPONT CO INC,STINE HASKELL RES CTR NEWARK DE 19714 DNAX RES INST MOL & CELLULAR BIOL INC PALO ALTO CA 94304
Titolo Testata:
The Journal of biological chemistry
fascicolo: 9, volume: 272, anno: 1997,
pagine: 5487 - 5494
SICI:
0021-9258(1997)272:9<5487:TETEOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
JAK-3 JANUS KINASE; ADHESION MOLECULE-1; SIGNAL-TRANSDUCTION; INTERFERON-ALPHA; TNF-ALPHA; TRANSCRIPTION FACTOR; GAMMA-CHAIN; PROTEINS; COMPONENT; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Lugli et al., "TUMOR-NECROSIS-FACTOR-ALPHA ENHANCES THE EXPRESSION OF THE INTERLEUKIN (IL)-4 RECEPTOR ALPHA-CHAIN ON ENDOTHELIAL-CELLS INCREASING IL-4 OR IL-13-INDUCED STAT6 ACTIVATION", The Journal of biological chemistry, 272(9), 1997, pp. 5487-5494

Abstract

Functional receptors for interleukin (IL)-4 and IL-13 on endothelial cells consist of the 130-kDa IL-4 receptor alpha-chain (IL-4R alpha) and a 65-75-kDa IL-13 binding subunit that are expressed in a ratio of about 1:3, respectively. The restricted number of IL-4R alpha limits subunit heterodimerization and in turn receptor-mediated signaling, We report here, the effects of tumor necrosis factor alpha (TNF-alpha) onthe expression of the receptor subunits for IL-4 and IL-13. By flow cytofluorometry and receptor-binding analysis of iodinated IL-4 and IL-13, stimulation with TNF-alpha-induced a 23-fold increase of the IL-4Ralpha expression, The up-regulation was also confirmed at the transcriptional level by reverse transcription-polymerase chain reaction, Radioligand cross-linking experiments revealed no change in the subunit composition of the TNF-alpha-induced receptor complex, Nevertheless, TNF-alpha stimulation led to increased activation of the IL-4-specific signal transducers and activators of transcription protein (Stat6) by IL-4 and IL-13. Thus, TNF-alpha corrects the subunit imbalance of the endothelial IL-4 IL-13 receptor complex thereby increasing receptor heterodimerization and in turn the signaling capability by IL-4 and IL-13.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 00:49:06