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Titolo:
31P-MAGNETIC RESONANCE SPECTROSCOPIC STUDY ON THE EFFECT OF GLYCEROL ON COLD-INDUCED BRAIN EDEMA
Autore:
KAMEZAWA T; ASAKURA T; YATSUSHIRO K; NIRRO M; KASAMO S; FUJIMOTO T;
Indirizzi:
KAGOSHIMA UNIV,SCH MED,DEPT NEUROSURG,8-35-1 SAKURAGAOKA KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,SCH MED,S JAPAN HLTH SCI CTR KAGOSHIMA 890 JAPAN
Titolo Testata:
Acta neurochirurgica
, , anno: 1994, supplemento:, 60
pagine: 499 - 501
SICI:
0001-6268(1994):<499:3RSSOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLISM;
Keywords:
BRAIN ENERGY METABOLISM; COLD-INDUCED BRAIN EDEMA; GLYCEROL; P-31 MAGNETIC RESONANCE SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
T. Kamezawa et al., "31P-MAGNETIC RESONANCE SPECTROSCOPIC STUDY ON THE EFFECT OF GLYCEROL ON COLD-INDUCED BRAIN EDEMA", Acta neurochirurgica, 1994, pp. 499-501

Abstract

The aim of the present study was to determine the effects of a hyperosmotic agent, 10% glycerol, on both brain energy metabolism and intracellular pH (pHi) in experimental vasogenic brain edema. Vasogenic brain edema was induced by cold injury applied to bilateral parietal portions in 13 mongrel dogs (7 glycerol, 6 control) while, 3 dogs were usedas control. Before and at 24 hours after the injury, sequential phosphorous-31 magnetic resonance spectroscopy (P-31-MRS) was performed for2 hours in order to determine phosphocreatine (PCr), beta-adenosine triphosphate (beta-ATP), inorganic phosphate (Pi) levels and pHi. At 24hours following cold injury, both PCr/Pi and ATP/Pi ratios significantly decreased from 7.75 to 3.97 and from 2.26 to 1.25, respectively. Furthermore, a moderate decrease in pHi of 7.16 to 7.01 was significantly demonstrated during the same experimental period. Administration ofglycerol for 30 minutes significantly increased PCr/Pi from 3.97 to 5.06 and ATP/Pi from 1.25 to 1.72, respectively. Also, glycerol administration caused a significant increase in pHi from 7.01 to 7.11. This study indicates that cryogenic injury, in which formation and expansionof vasogenic brain edema a known to occur, results in disturbed brainenergy metabolism and in intracellular acidosis; moreover, the administration of glycerol can ameliorate either or both of these derangements.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:16:01