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Titolo:
SEVERE BRAIN EDEMA ASSOCIATED WITH CUMULATIVE EFFECTS OF HYPONATREMICENCEPHALOPATHY AND ISCHEMIC HYPOXIA
Autore:
VEXLER ZS; ROBERTS TPL; KUCHARCZYK J; ARIEFF AI;
Indirizzi:
VETRANS AFFAIRS MED CTR,DEPT MED,GERIATR SECT,111G,4150 CLEMENT ST SAN FRANCISCO CA 94121 UNIV CALIF SAN FRANCISCO,NEURORADIOL SECT SAN FRANCISCO CA 94143
Titolo Testata:
Acta neurochirurgica
, , anno: 1994, supplemento:, 60
pagine: 246 - 249
SICI:
0001-6268(1994):<246:SBEAWC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; SYNAPTOSOMES; DAMAGE;
Keywords:
ISCHEMIA; HYPONATREMIA; SYNAPTOSOMES; SODIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
Z.S. Vexler et al., "SEVERE BRAIN EDEMA ASSOCIATED WITH CUMULATIVE EFFECTS OF HYPONATREMICENCEPHALOPATHY AND ISCHEMIC HYPOXIA", Acta neurochirurgica, 1994, pp. 246-249

Abstract

Hyponatremia in cats produced brain edema, detectable by both magnetic resonance imaging (MRI) and increased brain water, with a compensatory decrease of brain sodium. Sodium transport was measured in synaptosomes from hyponatremic cat cerebral cortex. The sodium efflux via Na+-K+-ATPase was significantly higher (144%) than control, while sodium influx via the Na+/H+ antiporter was significantly decreased (74%). Both responses tend to decrease brain intracellular sodium and thus, brain cell osmolality. Ischemia following unilateral middle cerebral artery occlusion also resulted in brain edema. However, the efflux of sodium via both Na+-K+-ATPase and sodium channels actually decreased, both maladaptive responses. Furthermore, when ischemia was superimposed upon hyponatremia, all of the cerebral adaptive changes which had been induced by hyponatremia alone were rendered ineffective. This resulted in further elevations of brain water and sodium. Hyponatremia superimposed upon ischemia thus worsens the brain edema associated with ischemia alone. Thus, ischemia impairs the ability of the brain to adapt to hyponatremia, probably by eliminating the compensatory mechanisms of brain sodium transport initiated by hyponatremia.

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Documento generato il 02/04/20 alle ore 11:14:47