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Titolo:
NEW METHOD FOR IMPROVING ACCURACY OF 24-HOUR CONTINUOUS INTRAGASTRIC PH-METRY - REFLECTIONS ON PHYSIOLOGICAL AND PHARMACOLOGICAL STUDIES
Autore:
MELA GS; SAVARINO V; MALESCI A; DIMARIO F; SOSSAI P; VIGNERI S; ZAMBOTTI A;
Indirizzi:
UNIV GENOA,DIPARTIMENTO MED INTERNA,VIALE BENEDETTO XV 6 I-16132 GENOA ITALY UNIV MILAN,IST MED INTERNA I-20122 MILAN ITALY UNIV PADUA,IST MED INTERNA PADUA ITALY OSPED CIVILE FELTRE,DIV MED PALERMO ITALY UNIV PALERMO,IST MED INTERNA & GERIATRIA PALERMO ITALY
Titolo Testata:
Digestive diseases and sciences
fascicolo: 7, volume: 39, anno: 1994,
pagine: 1416 - 1424
SICI:
0163-2116(1994)39:7<1416:NMFIAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC ASPIRATION; ACIDITY; ELECTRODE; ANTIMONY;
Keywords:
INTRAGASTRIC PH-METRY; CHRONIC ATROPHIC GASTRITIS; BENIGN GASTRIC ULCER; DUODENAL ULCER; H-2-ANTAGONIST DRUGS; FAMOTIDINE; NIZATIDINE; RANITIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
G.S. Mela et al., "NEW METHOD FOR IMPROVING ACCURACY OF 24-HOUR CONTINUOUS INTRAGASTRIC PH-METRY - REFLECTIONS ON PHYSIOLOGICAL AND PHARMACOLOGICAL STUDIES", Digestive diseases and sciences, 39(7), 1994, pp. 1416-1424

Abstract

Continuous 24-hr intragastric pH-metry was prospectively performed in801 subjects with different clinical conditions using two pH electrodes placed closely adjacent. The aim was to assess the in situ repeatability of the test and to verify whether the removal of artifacts, interference, and noise usually superimposed onto the fundamental signal recorded by the measuring apparatus improves the clinical usefulness ofexperimental data. The following debugging/filtering procedure was used: first, pH recordings of each channel were amended separately from artifacts, then they underwent 7 min windowed median interference debugging, and finally Wiener noise filtering was applied. Afterwards, the24-hr mean pH profile was obtained in each subject by averaging the pH tracings of the two channels every minute (1440 data points/24 hr). The efficiency of this procedure was assessed at each step by evaluating the difference among groups using the O'Brien test, a distribution-free nonparametric method well-suited for evaluating differences amonggroups allocated onto a two-way layout. The differences among groups calculated from raw pH data of the single channels can be very misleading, in that it is possible to find that they are significant on one channel and not significant on the other channel. Conversely, the significance of the differences among groups increases progressively at each step of the above debugging/filtering procedure applied to raw pH profiles of each channel. Seven minutes was shown to be the most suitable time lag for windowed median removal of interference. The whole procedure increases by 10 up to 10(8) times the probability of detecting differences among groups, particularly when one rules out pH tracings with a discrepancy time between the two channels which is more than 1 hr over the entire 24-hr period. Our results suggest that removal of artifacts, interference, and noise superimposed onto the endoluminal pH tracings can greatly improve the usefulness of 24-hr intragastric pH-metry in every clinical situation. Moreover, test reliability largely depends on the in situ reproduceability of pH measurements.

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Documento generato il 14/07/20 alle ore 06:57:21