Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SEPARATION OF CHINESE LEISHMANIA ISOLATES INTO 5 GENOTYPES BY KINETOPLAST AND CHROMOSOMAL DNA HETEROGENEITY
Autore:
LU HG; ZHONG L; GUAN LR; QU JQ; HU XS; CHAI JJ; XU ZB; WANG CT; CHANG KP;
Indirizzi:
UNIV HLTH SCI CHICAGO MED SCH,DEPT MICROBIOL IMMUNOL,3333 GREEN BAY RD N CHICAGO IL 60064 CHINESE ACAD MED SCI,INST PARASIT DIS SHANGHAI PEOPLES R CHINA W CHINA UNIV MED SCI,DEPT PARASITOL CHENGDU 610041 PEOPLES R CHINA INST ENDEM DIS XINJIANG PEOPLES R CHINA PEKING INST TROP MED BEIJING PEOPLES R CHINA SHANDONG INST PARASIT DIS JININ PEOPLES R CHINA
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 6, volume: 50, anno: 1994,
pagine: 763 - 770
SICI:
0002-9637(1994)50:6<763:SOCLII>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
KALA-AZAR; IDENTIFICATION; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H.G. Lu et al., "SEPARATION OF CHINESE LEISHMANIA ISOLATES INTO 5 GENOTYPES BY KINETOPLAST AND CHROMOSOMAL DNA HETEROGENEITY", The American journal of tropical medicine and hygiene, 50(6), 1994, pp. 763-770

Abstract

Leishmaniasis remains endemic in China, especially in the west and northwest frontier regions in central Asia, Epidemic outbreaks of both visceral and cutaneous forms of the disease have become a serious concern in view of such events occurring in neighboring countries. In the present study, we have begun to characterize available parasites as an initial step in understanding the epidemiology of leishmaniasis in central Asia. Nineteen Leishmania isolates collected since the 1950s fromepidemiologically different foci in China were separated into five genotypes (Groups I-V) based on their polymorphisms in both kinetoplast (kDNA) and nuclear (nDNA) DNAs. Both kDNA and nDNA are conserved in Group I, which consists of six isolates, i.e., five cases of human kala-azar and one case of canine leishmaniasis isolated from three distant foci more than 30 years apart. In contrast, both kDNA and nDNA are heterogeneous in Group II, consisting of 10 isolates scattered in the plain area from the eastern coast to the western desert. This group includes five kala-azar cases, one post-kala-azar dermal leishmaniasis case, two sand By isolates, and two canine isolates. The remaining three groups (III-V) two from great gerbils (Rhombomys opimus) and one from akala-azar case, differ among themselves and from the aforementioned groups. Groups I, II/III, IV, and V contain isolates that have been recognized epidemiologically or typed isoenzymatically as L. donovani s.l., L. infantum s.l., L. turinica, and L. gerbilli, respectively. Whileagreeing with this general grouping, the results suggest that the isolates are more heterogeneous than previously thought, necessitating the reassignment of some isolates into different groups. The results presented call for further characterization of additional isolates from different endemic foci for understanding the relationships of these Leishmania genotypes to the epidemiology of the clinical diseases they cause.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:02:12