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Titolo:
PROJECTIONS OF TACHYKININ-CONTAINING AND GLUTAMINASE-CONTAINING RAT RETINAL GANGLION-CELLS
Autore:
MIGUELHIDALGO JJ; SENBA E; TAKATSUJI K; TOHYAMA M;
Indirizzi:
TOLEDO,N-12,3-B E-37005 SALAMANCA SPAIN OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI SUITA OSAKA 565 JAPAN
Titolo Testata:
Brain research bulletin
fascicolo: 1, volume: 35, anno: 1994,
pagine: 73 - 84
SICI:
0361-9230(1994)35:1<73:POTAGR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUPILLARY LIGHT REFLEX; AMINOTRANSFERASE-LIKE IMMUNOREACTIVITY; OLIVARY PRETECTAL NUCLEUS; SUBSTANCE-P; SUPERIOR COLLICULUS; OPTIC TECTUM; GUINEA-PIG; EXCITATORY TRANSMITTER; ADENOSINE-DEAMINASE; ANATOMICAL ANALYSIS;
Keywords:
SUBSTANCE P; GLUTAMINASE; RETINAL GANGLION CELLS; PRETECTAL OLIVARY NUCLEUS; TACHYKININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Miguelhidalgo et al., "PROJECTIONS OF TACHYKININ-CONTAINING AND GLUTAMINASE-CONTAINING RAT RETINAL GANGLION-CELLS", Brain research bulletin, 35(1), 1994, pp. 73-84

Abstract

Glutamate (Glu) and the tachykinin substance P (SP) have been proposed as neurotransmitters or neuromodulators of the retinal projection tothe brain. In the present study, we demonstrate that tachykinin-like (TK) immunoreactivity (IR) accumulates in rat retinal axons following electrical lesions to the optic tract, indicating that SP is conveyed in the optic nerve to its central targets. In addition, we show that eye enucleation causes a dramatic decrease in TK-IR fibers in the pretectal olivary nucleus (PON), but not in other retinorecipient nuclei ofthe thalamus and the midbrain, and that Fluorogold injected into the pretectum is retrogradely transported to the somata of TK-IR retinal ganglion cells (RGCs), indicating an important projection of TK-IR RGCsto the PON. We also show that most rat RGCs are labeled with antibodies against phosphate-activated glutaminase, an enzyme considered to generate the transmitter pool of glutamate. Unlike TK-IR fibers, phosphate-activated glutaminase-IR structures disappear in most retinorecipient nuclei following eye enucleation. The present results give neuroanatomical support to the idea that glutamate is a neurotransmitter in the retinal projection and suggest an important role for TK-IR RGCs in the relay of visual information to the PON.

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Documento generato il 08/07/20 alle ore 08:07:56