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Titolo:
PATHOPHYSIOLOGICAL PROCESS AFTER TRANSIENT ISCHEMIA OF THE MIDDLE CEREBRAL-ARTERY IN THE RAT
Autore:
NISHINO H; CZURKO A; FUKUDA A; HASHITANI T; HIDA H; KARADI Z; LENARD L;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PHYSIOL,MIZUHO KU NAGOYA AICHI 467 JAPAN UNIV PECS,SCH MED,INST PHYSIOL H-7643 PECS HUNGARY
Titolo Testata:
Brain research bulletin
fascicolo: 1, volume: 35, anno: 1994,
pagine: 51 - 56
SICI:
0361-9230(1994)35:1<51:PPATIO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOREBRAIN ISCHEMIA; DARK NEURONS; HIPPOCAMPUS; DEGENERATION; TISSUE; DAMAGE; MODEL; BRAIN; EDEMA;
Keywords:
ISCHEMIA; ARGYROPHILIA; SERUM PROTEIN; IGG; COMPLEMENT C3; BLOOD-BRAIN BARRIER; STRIATUM; CORTEX; MIDDLE CEREBRAL ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
H. Nishino et al., "PATHOPHYSIOLOGICAL PROCESS AFTER TRANSIENT ISCHEMIA OF THE MIDDLE CEREBRAL-ARTERY IN THE RAT", Brain research bulletin, 35(1), 1994, pp. 51-56

Abstract

For the understanding of pathophysiology of the cerebral ischemia, wemade a transient intraluminal occlusion of the middle cerebral arteryin the rat and investigated the appearance of collapsed dark neurons and the extravasation of serum proteins using argyrophil III method and immunohistochemistry. In the acute stage (minutes to 3 days), dark neurons appeared in the lateral half of the ipsilateral striatum and adjacent cortex which formed the ischemic core of this model. Dark neurons also appeared in the ipsilateral reticular thalamic nucleus, hippocampus, and amygdala. The extravasation of serum proteins, albumin, leucocyte common antigen, immunoglobulin G, complement factor C3, as wellas heat shock protein 70, was observed not only in the ischemic but sometimes also in the contralateral hemisphere. Among these, the expression of IgG and C3 was most prominent in the ischemic core. In the chronic stage (1 to 3 months), the ischemic core changed into the porencephaly, and the ventrobasal nucleus of the thalamus got also involved in the necrosis. A strong microgliosis was observed in the substantia nigra pars reticulata. Data suggest, that among many mechanisms that contribute to ischemic neuronal death, the activation of immune response, due to the damage of blood-brain barrier and the extravasation of serum proteins could promote the ischemic cell death in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:21:29