Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE INVOLVEMENT OF CGRP IN ACETYLCHOLINE-INDUCED VASCULAR RELAXATION
Autore:
SCOTT TM; CHAFE L;
Indirizzi:
MEM UNIV NEWFOUNDLAND,FAC MED ST JOHNS A1B 3V6 NEWFOUNDLAND CANADA
Titolo Testata:
Artery
fascicolo: 1, volume: 21, anno: 1994,
pagine: 38 - 50
SICI:
0098-6127(1994)21:1<38:TIOCIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; MESENTERIC ARTERIAL BED; SUBSTANCE-P; CEREBROVASCULAR NERVES; SENSORY NERVES; CO-EXISTENCE; NITRIC-OXIDE; RAT; ENDOTHELIUM; STIMULATION;
Keywords:
CGRP; ACETYLCHOLINE; VASCULAR RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Scott e L. Chafe, "THE INVOLVEMENT OF CGRP IN ACETYLCHOLINE-INDUCED VASCULAR RELAXATION", Artery, 21(1), 1994, pp. 38-50

Abstract

Earlier work on peptidergic fibres suggested some involvement of CGRPperivascular nerve fibres in acetylcholine-induced endothelium-dependent vascular relaxation. We have investigated the effect of blocking CGRP receptors and CGRP replacement on acetylcholine-induced endothelium-dependent vascular relaxation in the isolated perfused mesenteric arterial bed in normal Sprague-Dawley rats and in rats seven days following freeze-denervation of the superior mesenteric artery. Freeze-denervation was carried out under pentobarbital anesthesia (40 mg/Kg). It was found that the ability of acetylcholine to cause relaxation was reduced by CGRP receptor blocking with CGRP8-37 in vessels from control rats, but returned to pre-blocking levels after washout of the antagonist. Treatment with CGRP increased the relaxation due to acetylcholine in denervated vessel beds, but not in control tissues. The CGRP receptor appears to be involved in the acetylcholine-induced relaxation of blood vessels. The mechanism of action is not known, although both acetylcholine and CGRP, act through activation of K+ channels, and CGRP may facilitate the activation of K+ channels by acetylcholine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:11:08