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Titolo:
KINETOPLAST DNA-REPLICATION - MECHANISTIC DIFFERENCES BETWEEN TRYPANOSOMA-BRUCEI AND CRITHIDIA-FASCICULATA
Autore:
FERGUSON ML; TORRI AF; PEREZMORGA D; WARD DC; ENGLUND PT;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM,725 N WOLFE ST BALTIMORE MD21205 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM BALTIMORE MD 21205 YALE UNIV,SCH MED,DEPT MOLEC BIOPHYS & BIOCHEM NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT GENET NEW HAVEN CT 06510
Titolo Testata:
The Journal of cell biology
fascicolo: 3, volume: 126, anno: 1994,
pagine: 631 - 639
SICI:
0021-9525(1994)126:3<631:KD-MDB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-STREAM; CELL-CYCLE; 2 SITES; NETWORKS; MINICIRCLES; LOCALIZATION; TRANSCRIPTION; MAXICIRCLES; EQUIPERDUM; EVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Ferguson et al., "KINETOPLAST DNA-REPLICATION - MECHANISTIC DIFFERENCES BETWEEN TRYPANOSOMA-BRUCEI AND CRITHIDIA-FASCICULATA", The Journal of cell biology, 126(3), 1994, pp. 631-639

Abstract

Kinetoplast DNA, the mitochondrial DNA of trypanosomatid parasites, is a network containing several thousand minicircles and a few dozen maxicircles. We compared kinetoplast DNA replication in Trypanosoma brucei and Crithidia fasciculata using fluorescence in situ hybridization and electron microscopy of isolated networks. One difference is in thelocation of maxicircles in situ. In C. fasciculata, maxicircles are concentrated in discrete foci embedded in the kinetoplast disk; during replication the foci increase in number but remain scattered throughout the disk. In contrast, T. brucei maxicircles generally fill the entire disk. Unlike those in C. fasciculata, T. brucei maxicircles become highly concentrated in the central region of the kinetoplast after replication; then during segregation they redistribute throughout the daughter kinetoplasts. T. brucei and C. fasciculata also differ in the pattern of attachment of newly synthesized minicircles to the network. In C. fasciculata it was known that minicircles are attached at two antipodal sites but subsequently are found uniformly distributed around the network periphery, possibly due to a relative movement of the kinetoplast disk and two protein complexes responsible for minicircle synthesis and attachment. In T. brucei, minicircles appear to be attached at two antipodal sites but then remain concentrated in these two regions. Therefore, the relative movement of the kinetoplast and the two protein complexes may not occur in T. brucei.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:51:45