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Titolo:
REVERSAL OF MUSCLE HYPERTROPHY IN THE RAT URINARY-BLADDER AFTER REMOVAL OF URETHRAL OBSTRUCTION
Autore:
GABELLA G; UVELIUS B;
Indirizzi:
UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,GOWER ST LONDON WC1E 6BT ENGLAND UNIV LUND HOSP,DEPT UROL LUND SWEDEN
Titolo Testata:
Cell and tissue research
fascicolo: 2, volume: 277, anno: 1994,
pagine: 333 - 339
SICI:
0302-766X(1994)277:2<333:ROMHIT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; SMOOTH-MUSCLE; DETRUSOR; COLLAGEN; PURIFICATION; PATHWAYS; MODEL; PIG;
Keywords:
URINARY BLADDER; SMOOTH MUSCLE; HYPERTROPHY; RAT (SPAGUE DAWLEY);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
G. Gabella e B. Uvelius, "REVERSAL OF MUSCLE HYPERTROPHY IN THE RAT URINARY-BLADDER AFTER REMOVAL OF URETHRAL OBSTRUCTION", Cell and tissue research, 277(2), 1994, pp. 333-339

Abstract

We studied the ultrastructure of the bladder musculature after first inducing hypertrophy by means of urethral obstruction and subsequentlyremoving the obstruction. With hypertrophy the bladder musculature increases ten-fold or more in volume; after de-obstruction approximately4/5 of the hypertrophic muscle weight and volume is lost within six weeks. In spite of this very large decrease in muscle mass there is no degeneration of muscle cells or nerve endings or of other cell types in the de-obstructed bladder either at 5 days or at 6 weeks. The individual muscle cells are smaller in size than in the hypertrophic bladderbut still larger than control muscle cells. The decrease in muscle cell size is more substantial than the decrease in muscle cell surface. There are no lysosomes or other signs of intracellular degradation in any cells of the muscle layer. The musculature contains a very large amount of intercellular material, mainly collagen. This study documentsthe great plasticity of the musculature in the reduction of muscle mass after de-obstruction. However, some of the fine structural featuresare almost as different from the controls as in the hypertrophic muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:48:08