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Titolo:
EXPRESSION OF MATRIX METALLOPROTEINASES-1 AND METALLOPROTEINASES-2 GENES IN A POSSIBLE ASSOCIATION WITH METASTATIC ABILITIES OF HUMAN PANCREATIC-CANCER CELLS
Autore:
JIMI S; SHONO T; ONO M; KUWANO M; TANAKA M; LOPEZOTIN C; KONO A;
Indirizzi:
KYUSHU UNIV,SCH MED,DEPT BIOCHEM,HIGASHI KU,MAIDASHI 3-1-1 FUKUOKA 81282 JAPAN KYUSHU UNIV,SCH MED,DEPT SURG 1,HIGASHI KU FUKUOKA 81282 JAPAN UNIV OVIEDO,FAC MED,DEPT BIOQUIM & BIOL MOL E-33006 OVIEDO SPAIN KYUSHU NATL CANC CTR,CHEMOTHERAPY DIV,RES INST FUKUOKA 816 JAPAN
Titolo Testata:
International journal of oncology
fascicolo: 3, volume: 10, anno: 1997,
pagine: 623 - 628
SICI:
1019-6439(1997)10:3<623:EOMMAM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; TISSUE INHIBITOR; NUDE-MICE; TUBULAR MORPHOGENESIS; UROKINASE RECEPTOR; ENDOTHELIAL-CELLS; TUMOR-METASTASIS; LINES; INVASION; COLLAGENASE;
Keywords:
LIVER METASTASIS; PANCREATIC CANCER; MATRIX METALLOPROTEINASE (MMP); TISSUE INHIBITOR OF METALLOPROTEINASE (TIMP); PLASMINOGEN ACTIVATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S. Jimi et al., "EXPRESSION OF MATRIX METALLOPROTEINASES-1 AND METALLOPROTEINASES-2 GENES IN A POSSIBLE ASSOCIATION WITH METASTATIC ABILITIES OF HUMAN PANCREATIC-CANCER CELLS", International journal of oncology, 10(3), 1997, pp. 623-628

Abstract

We determined if any extracellular matrix degradative proteases were possibly associated with metastatic potentials of human pancreatic cancer cells. Liver metastatic abilities of six human pancreatic cancer cell lines were examined in nude mice, and divided into two high (2 lines) and low (4 lines) metastatic cell lines. Of six cell lines, matrixmetalloproteinases-1 (MMP-1) was overexpressed in two high metastaticcell lines: and MMP-2 was overexpressed in one high metastatic cell line. Of the four low metastatic lines, two cell lines had relatively higher mRNA levels of tissue inhibitors of metalloproteinases-3 (TIMP-3). MMP activities due to MMP-1 and MMP-2 might be positively associated with liver metastasis of pancreatic cancer cells. Moreover, expression of TIMP-3 might be partly involved in the low metastatic potentialsof pancreatic cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:27:26