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Titolo:
TESTING GARLIC FOR POSSIBLE ANTIAGING EFFECTS ON LONG-TERM GROWTH-CHARACTERISTICS, MORPHOLOGY AND MACROMOLECULAR-SYNTHESIS OF HUMAN FIBROBLASTS IN CULTURE
Autore:
SVENDSEN L; RATTAN SIS; CLARK BFC;
Indirizzi:
AARHUS UNIV,DEPT CHEM,CELLULAR AGING LAB,LANGELANDSGADE 140 DK-8000 AARHUS C DENMARK AARHUS UNIV,DEPT CHEM,CELLULAR AGING LAB DK-8000 AARHUS C DENMARK
Titolo Testata:
Journal of ethnopharmacology
fascicolo: 2, volume: 43, anno: 1994,
pagine: 125 - 133
SICI:
0378-8741(1994)43:2<125:TGFPAE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACTS; SATIVUM;
Keywords:
GARLIC; AGING; ANTIAGING; SKIN; FIBROBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Svendsen et al., "TESTING GARLIC FOR POSSIBLE ANTIAGING EFFECTS ON LONG-TERM GROWTH-CHARACTERISTICS, MORPHOLOGY AND MACROMOLECULAR-SYNTHESIS OF HUMAN FIBROBLASTS IN CULTURE", Journal of ethnopharmacology, 43(2), 1994, pp. 125-133

Abstract

The beneficial effects claimed for the use of garlic as a nutritionalsupplement include detoxification, antioxidation, antifungal activity, antibacterial activity, tumour suppression and, possibly, anti-ageing and rejuvenating effects. We have used the Hayflick system of cellular ageing in culture in order to test garlic for its anti-ageing effects on long-term growth characteristics, morphology and macromolecular synthesis of human skin fibroblasts. Our results show that an additionof garlic extract into the normal eel culture medium can support serial subculturing for over more than 55 population doublings in 475 days, and that this treatment has some youth-preserving, anti-ageing and beneficial effects on human fibroblasts in terms of maximum proliferative capacity and morphological characteristics. In comparison, similar or lesser doses of garlic extracts are growth inhibitory for cancerouscells that could not be grown over longer periods in the presence of garlic. To our knowledge, this is the first report of the effects of garlic on the long-term growth characteristics and macromolecular synthesis of normal human skin cells, the results of which have applications for both anti-ageing and anti-cancer research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:31:54