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Titolo:
INDUCTION OF INSULIN-RESISTANCE BY ANDROGENS AND ESTROGENS
Autore:
POLDERMAN KH; GOOREN LJG; ASSCHEMAN H; BAKKER A; HEINE RJ;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL,POB 7057 1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL 1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 1, volume: 79, anno: 1994,
pagine: 265 - 271
SICI:
0021-972X(1994)79:1<265:IOIBAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC OVARIAN DISEASE; ORAL-CONTRACEPTIVE AGENTS; GLUCOSE-TOLERANCE; CARBOHYDRATE-METABOLISM; PLASMA-INSULIN; NORMAL WOMEN; NORMAL MEN; SENSITIVITY; HYPERANDROGENISM; TESTOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Polderman et al., "INDUCTION OF INSULIN-RESISTANCE BY ANDROGENS AND ESTROGENS", The Journal of clinical endocrinology and metabolism, 79(1), 1994, pp. 265-271

Abstract

Hyperinsulinemia is a common finding in hyperandrogenic women, duringpregnancy, and in women using oral contraceptives. To test whether sex hormone treatment can induce insulin resistance in healthy subjects,we studied the effects of administration of testosterone to 13 femaleto male and of ethinyl estradiol to 18 male to female transsexuals. Utilization and production of glucose and levels of sex steroids were measured during a three-step hyperinsulinemic-euglycemic clamp before and after 4 months of hormone administration. Females were treated withim injections of testosterone esters (250 mg/2 weeks); males were treated with ethinyl estradiol alone (0.1 mg/day, orally) or a combination of ethinyl estradiol and cyproterone acetate (100 mg/day, orally). Similar insulin levels were achieved at each of the three steps of the clamp studies before and during hormone administration. During step 1 of each clamp, with insulin levels in the physiological range, glucoseutilization decreased from 3.5 +/- 1.2 to 2.6 +/- 0.9 mmol/kg lean body mass (LBM).h in women treated with testosterone esters (P < 0.001) and from 3.2 +/- 0.7 to 2.5 +/- 0.5 mmol/kg lean body mass h in men treated with ethinyl estradiol (P < 0.001). The effects of sex steroids during steps 2 and 3 of the clamp at higher (supraphysiological) insulin levels were less clear. Endogenous glucose production (measured by isotope dilution with tritiated glucose) was not affected by hormone administration, indicating that the observed changes in glucose requirement were determined by a diminished peripheral glucose uptake. We conclude that sex hormone administration, i.e. testosterone treatment in females and ethinyl estradiol treatment in males, can induce insulin resistance in healthy subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:13:14