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Titolo:
HIPPOCAMPAL INTERNEURONS EXPRESS A NOVEL FORM OF SYNAPTIC PLASTICITY
Autore:
MCMAHON LL; KAUER JA;
Indirizzi:
DUKE UNIV,MED CTR,DEPT NEUROBIOL DURHAM NC 27710
Titolo Testata:
Neuron
fascicolo: 2, volume: 18, anno: 1997,
pagine: 295 - 305
SICI:
0896-6273(1997)18:2<295:HIEANF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; GUINEA-PIG HIPPOCAMPUS; LACUNOSUM-MOLECULARE INTERNEURONS; EPSP SPIKE DISSOCIATION; RAT HIPPOCAMPUS; LASTING POTENTIATION; PYRAMIDAL CELLS; PERFORANT PATH; DENTATE GYRUS; INTRADENDRITIC RECORDINGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
L.L. Mcmahon e J.A. Kauer, "HIPPOCAMPAL INTERNEURONS EXPRESS A NOVEL FORM OF SYNAPTIC PLASTICITY", Neuron, 18(2), 1997, pp. 295-305

Abstract

Individual GABAergic interneurons in hippocampus can powerfully inhibit more than a thousand excitatory pyramidal neurons. Therefore, control of interneuron excitability provides control over hippocampal networks. We have identified a novel mechanism in hippocampus that weakens excitatory synapses onto GABAergic interneurons. Following stimulationthat elicits long-term potentiation at neighboring synapses onto excitatory cells, excitatory synapses onto inhibitory interneurons undergoa long-term synaptic depression (interneuron LTD; iLTD). Unlike most other forms of hippocampal synaptic plasticity, iLTD is not synapse specific: stimulation of an afferent pathway triggers depression not only of activated synapses but also of inactive excitatory synapses onto the same interneuron. These results suggest that high frequency afferent activity increases hippocampal excitability through a dual mechanism, simultaneously potentiating synapses onto excitatory neurons and depressing synapses onto inhibitory neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:32:30