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Titolo:
DOPAMINE-D2 RECEPTOR BLOCKADE AND ANTIMIGRAINE ACTION OF FLUNARIZINE
Autore:
WOBER C; BRUCKE T; WOBERBINGOL C; ASENBAUM S; WESSELY P; PODREKA I;
Indirizzi:
UNIV VIENNA,DEPT NEUROL,NEUROL KLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA
Titolo Testata:
Cephalalgia
fascicolo: 3, volume: 14, anno: 1994,
pagine: 235 - 240
SICI:
0333-1024(1994)14:3<235:DRBAAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIGRAINE; DEPRESSION; SECRETION; AGENTS;
Keywords:
DOPAMINE-D2 RECEPTORS; FLUNARIZINE; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C. Wober et al., "DOPAMINE-D2 RECEPTOR BLOCKADE AND ANTIMIGRAINE ACTION OF FLUNARIZINE", Cephalalgia, 14(3), 1994, pp. 235-240

Abstract

We studied in vivo the influence of flunarizine on dopamine D2 receptors and investigated whether dopamine D2 receptor blockade is involvedin its antimigraine action. Eleven migraine patients, treated with flunarizine, 10 mg per day, underwent single photon emission computer tomography (SPECT) using [I-123] labeled iodobenzamide, a ligand with high affinity and high specificity for D2 receptors. There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls. The efficacy of flunarizine in migraine prophylaxis failed to correlate with the degree of the dopamine D2 receptor blockade. The antimigraine action of flunarizine may not involve antidopaminergic mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:47:53