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Titolo:
CELL-TYPE-SPECIFIC ORGANIZATION OF GLYCINE RECEPTOR CLUSTERS IN THE MAMMALIAN SPINAL-CORD
Autore:
ALVAREZ FJ; DEWEY DE; HARRINGTON DA; FYFFE REW;
Indirizzi:
WRIGHT STATE UNIV,DEPT ANAT,3640 COL GLENN HWY DAYTON OH 45435
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 379, anno: 1997,
pagine: 150 - 170
SICI:
0021-9967(1997)379:1<150:COOGRC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE AFFERENT-FIBERS; CENTRAL-NERVOUS-SYSTEM; RECURRENT INHIBITION; ELECTRICAL-STIMULATION; QUANTAL ANALYSIS; SYNAPTIC POTENTIALS; PROTEIN GEPHYRIN; CENTRAL SYNAPSES; RENSHAW CELLS; CAT;
Keywords:
GEPHYRIN; MOTONEURONS; IA INHIBITORY INTERNEURONS; RENSHAW CELLS; SYNAPTIC ACTIVE ZONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
F.J. Alvarez et al., "CELL-TYPE-SPECIFIC ORGANIZATION OF GLYCINE RECEPTOR CLUSTERS IN THE MAMMALIAN SPINAL-CORD", Journal of comparative neurology, 379(1), 1997, pp. 150-170

Abstract

Glycinergic synapses play a major role in shaping the activity of spinal cord neurons. The spatial organization of postsynaptic receptors is likely to determine many functional parameters at these synapses andis probably related to the integrative capabilities of different neurons. In the present study we have investigated the organization of gephyrin expression along the dendritic membranes of alpha- and gamma-motoneurons, Ia inhibitory interneurons, and Renshaw cells. Gephyrin is aprotein responsible for the postsynaptic clustering of glycine receptors, and the features of gephyrin and glycine receptor alpha(1)-subunit immunofluorescent clusters displayed similar characteristics on ventral horn spinal neurons. However, the density of clusters and their topographical organization and architecture varied widely in different neurons and in different dendritic regions. For motoneurons and Ia inhibitory interneurons, cluster size and complexity increased with distance fr om the soma, perhaps as a mechanism to enhance the influence of distal synapses. Renshaw cells were special in that they displayed an abundant complement of large and morphologically complex clusters concentrated in their somas and proximal dendrites. Serial electron microscopy confirmed that the various immunoreactivity patterns observed with immunofluorescence accurately parallel the variable organization of pre- and postsynaptic active zones of glycinergic synapses. Finally, synaptic boutons from single-labeled axons of glycinergic neurons (Ia inhibitory interneurons) were also associated with postsynaptic receptor clusters of variable shapes and configurations. Our results indicatethat mechanisms regulating receptor clustering do so primarily in thecontext of the postsynaptic neuron identity and localization in the dendritic arbor. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:19:14