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Titolo:
MOLECULAR ANATOMY OF THE DEVELOPMENT OF THE HUMAN SUBSTANTIA-NIGRA
Autore:
AUBERT I; BRANA C; PELLEVOISIN C; GIROS B; CAILLE I; CARLES D; VITAL C; BLOCH B;
Indirizzi:
UNIV BORDEAUX 2,UMR CNRS 5541,LAB HISTOL EMBRYOL,146 RUE LEO SAIGNAT F-33076 BORDEAUX FRANCE HOP PELLEGRIN,SERV ANAT PATHOL F-33076 BORDEAUX FRANCE FAC PHARM,BIOPHYS LAB,INSERM U316 F-37200 TOURS FRANCE UNIV PARIS 06,LAB NEUROBIOL CELLULAIRE & FONCT,INSERM U288 F-75634 PARIS 13 FRANCE
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 379, anno: 1997,
pagine: 72 - 87
SICI:
0021-9967(1997)379:1<72:MAOTDO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2 DOPAMINE-RECEPTOR; TRANSPORTER MESSENGER-RNA; TYROSINE-HYDROXYLASE IMMUNOREACTIVITY; CATECHOLAMINERGIC CELL GROUPS; RAT STRIATAL NEURONS; GENE-EXPRESSION; INSITU HYBRIDIZATION; PARKINSONS-DISEASE; MESENCEPHALIC NEURONS; NERVOUS-SYSTEM;
Keywords:
DOPAMINERGIC MARKERS; HUMAN FETAL BRAIN; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
I. Aubert et al., "MOLECULAR ANATOMY OF THE DEVELOPMENT OF THE HUMAN SUBSTANTIA-NIGRA", Journal of comparative neurology, 379(1), 1997, pp. 72-87

Abstract

A series of 15 fetal and perinatal human brains (from week 12 of fetal life to day 2 after birth) was studied in order to describe the anatomical and molecular correlates of the substantia nigra ontogeny. In situ hybridization, Immunohistochemistry and binding studies were used to detect D-2 dopamine receptor (D2R) mRNA, D2R binding sites, dopamine membrane transporter (DAT) mRNA, tyrosine hydroxylase (TH) protein, D-1 dopamine receptor (D1R) protein and D1R binding sites. Dopaminergic (DA) neurons of the substantia nigra were detected through TH immunoreactivity from week 12. At week 16, the substantia nigra was clearly delineated as a compact group of intermingled neurons and fibers. Fromweek 19, groups of DA neurons mere segregated from the pars reticulata. These groups have been divided into the substantia nigra pars compacta, the ventral tegmental area and the retrorubral area. The DA neurons exhibited a gradual increase in size and branching development until bir th. From week 12 onward they expressed several other markers of dopamine transmission, i.e., D2R mRNA, D2R binding sites and DAT mRNA. The ventral tegmental area expressed lower levels of mRNA for DAT andD2R than the pars compacta. From week 12, D1R immunoreactivity and D1R binding sites mere also present in the substantia nigra pars reticulata. This suggests that projecting striatonigral neurons, known to express the D1R gene, have developed pathways connecting with the substantia nigra by week 12. Our results demonstrate that the developing substantia nigra in human displays early transcriptional and translationalactivity for the main constituents of dopaminergic transmission from week 12 and receives at this time dopaminoceptive inputs bearing D1 receptors from the striatum. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:34:30