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Titolo:
SPECIES-DIFFERENCES IN THE CARDIOVASCULAR-RESPONSES TO HISTAMINE H-3 RECEPTOR ACTIVATION
Autore:
MCLEOD RL; GERTNER SB; HEY JA;
Indirizzi:
SCHERING PLOUGH CORP,RES INST,CNS PHARMACOL,2015 GALLOPING HILL RD KENILWORTH NJ 07033 SCHERING PLOUGH CORP,RES INST,ALLERGY KENILWORTH NJ 07033 UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT PHARMACOL & TOXICOL NEWARK NJ 07103
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 259, anno: 1994,
pagine: 211 - 214
SICI:
0014-2999(1994)259:2<211:SITCTH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIGS; H3 RECEPTORS; INHIBITION; H3-RECEPTORS;
Keywords:
HISTAMINE H-3 RECEPTOR; R-ALPHA-METHYLHISTAMINE; SPECIES DIFFERENCE; PRESYNAPTIC INHIBITION; THIOPERAMIDE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Mcleod et al., "SPECIES-DIFFERENCES IN THE CARDIOVASCULAR-RESPONSES TO HISTAMINE H-3 RECEPTOR ACTIVATION", European journal of pharmacology, 259(2), 1994, pp. 211-214

Abstract

Potential species differences in cardiovascular responses to histamine H-3 receptor activation were studied in the conscious guinea pig, rabbit, normotensive rat and the spontaneously hypertensive rat. R-alpha-Methylhistamine (100 mu g/kg i.v.) decreased blood pressure in both the guinea pig and the rabbit. In the guinea pig, R-alpha-methylhistamine decreased heart rate, whereas in the rabbit it produced a tachycardia. In the normotensive rat and spontaneously hypertensive rat, R-alpha-methylhistamine (100 mu g/kg i.v.) had no effect on blood pressure and heart rate. The cardiovascular action of R-alpha-methylhistaminn inthe guinea pig and rabbit was blocked by pretreatment with thioperamide (1.0 mg/kg i.v.) but not by chlorpheniramine (0.3 mg/kg i.v.) or cimetidine (3.0 mg/kg i.v.), respectively. These results indicate species differences in cardiovascular responses to histamine H-3 receptor activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/01/21 alle ore 23:52:06