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Titolo:
CHRONIC EFFECTS OF ETHANOL ON CENTRAL ADENOSINE FUNCTION OF MICE
Autore:
DALY JW; SHI D; WONG V; NIKODIJEVIC O;
Indirizzi:
NIH,BIOORGAN CHEM LAB,BLDG 8,RM 1A17 BETHESDA MD 20892
Titolo Testata:
Brain research
fascicolo: 1, volume: 650, anno: 1994,
pagine: 153 - 156
SICI:
0006-8993(1994)650:1<153:CEOEOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MOTOR INCOORDINATION; SHORT-SLEEP MICE; LOCOMOTOR-ACTIVITY; CALCIUM CHANNELS; MOUSE-BRAIN; LONG-SLEEP; TOLERANCE; RECEPTORS; CAFFEINE; SEROTONIN;
Keywords:
ETHANOL; ADENOSINE RECEPTOR; LOCOMOTOR ACTIVITY; CALCIUM CHANNEL; CAFFEINE; DIHYDROPYRIDINE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Daly et al., "CHRONIC EFFECTS OF ETHANOL ON CENTRAL ADENOSINE FUNCTION OF MICE", Brain research, 650(1), 1994, pp. 153-156

Abstract

Chronic ingestion of 5% ethanol had no significant effect on open field locomotor of NIH Swiss strain male mice, nor were the depressant effects of a non-selective adenosine receptor agonist, NECA, or the stimulant effects of a non-selective antagonist, caffeine significantly altered. The density of cerebral cortical A(1)-adenosine receptors and of nitrendipine binding sites on calcium channels were significantly increased after chronic ethanol, while the density of striatal A(2a)-adenosine receptors were unchanged. The locomotor stimulant effects of ethanol (2.5 g/kg) were slightly decreased after chronic ethanol, but were markedly reduced in mice after chronic caffeine ingestion. The results suggest some involvement of adenosine systems in the effects of ethanol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:07:10