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Titolo:
CAUDAL VENTROLATERAL MEDULLARY DEPRESSOR AREA CONTROLS CEREBRAL-CIRCULATION VIA ROSTRAL VENTROLATERAL MEDULLARY PRESSER AREA
Autore:
MAEDA M; INOUE M; TAKAO S; HAYASHIDA Y; NAKAI M; KRIEGER AJ; SAPRU HN;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,DEPT SYST PHYSIOL,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU 807 FUKUOKA JAPAN FUKUOKA UNIV,SCH MED,DEPT NEUROSURG FUKUOKA 81401 JAPAN NATL CARDIOVASC CTR OSAKA JAPAN UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,NEUROL SURG SECT NEWARKNJ 07103
Titolo Testata:
Pflugers Archiv
fascicolo: 5-6, volume: 427, anno: 1994,
pagine: 556 - 558
SICI:
0031-6768(1994)427:5-6<556:CVMDAC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICAL-STIMULATION; BLOOD-FLOW; ANESTHETIZED RATS;
Keywords:
CEREBROVASCULAR CIRCULATION; CARDIOVASCULAR CENTER; VENTROLATERAL MEDULLA; VASOMOTOR SYSTEM; CERVICAL SYMPATHETIC NERVE; REGIONAL DIFFERENTIATION OF THE SYMPATHETIC NERVES ACTIVITIES; SYMPATHETIC NERVE; NEURAL PATHWAY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
M. Maeda et al., "CAUDAL VENTROLATERAL MEDULLARY DEPRESSOR AREA CONTROLS CEREBRAL-CIRCULATION VIA ROSTRAL VENTROLATERAL MEDULLARY PRESSER AREA", Pflugers Archiv, 427(5-6), 1994, pp. 556-558

Abstract

The cerebral bleed flow (CBF) ass determined by radiolabeled microsphere technique in urethane (1.1-1.5 g kg i.p.) anesthetized Wistar rats. Microinjection of L-glutamate (1.7 nmol) into the ventrolateral medullary depressor area (VLDA) produced a significant (P<0.01) decrease in CBF from 64 +/- 9 (mean +/- S.E.M.) to 48 +/- 9 ml.min(-1).(100g)(-1) and a significant (P<0.01) increase in cerebrovascular resistance (CVR) from 1.7 +/- 0.2 to 2.4 +/- 0.4 mmHg per [ml.min(-1).(100g)(-1)] in the cerebral cortex ipsilateral to the stimulated VLDA side but not in other structures such as brain stem and cerebellum (n=9). Cervical sympathectomy blocked the decrease in CBF and increase in CVR elicitedby chemical stimulation of the VLDA (n=10). Depression of the ventrolateral medullary presser area (VLPA) neurons induced by microinjectionof muscimol into the VLPA blocked the CBF decrease and CVR increase following chemical stimulation of the VLDA (n=11). Microinjection of the vehicle solution into the VLDA had no effects on systemic and cerebral circulation (n=7). These results suggest that a vasoconstrictor pathway to control cerebral vessels involves an excitatory projection from the VLDA to the VLPA and the changes in cerebral circulation are mediated by the cervical sympathetic nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:12:50