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Titolo:
DIFFERENTIAL REQUIREMENTS FOR P21(RAS) AND PROTEIN-KINASE-C IN THE REGULATION OF NEURONAL GENE-EXPRESSION BY NERVE GROWTH-FACTOR AND NEUROKINES
Autore:
JOHNSON JA; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,SJ-30 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
The Journal of biological chemistry
fascicolo: 29, volume: 269, anno: 1994,
pagine: 18856 - 18863
SICI:
0021-9258(1994)269:29<18856:DRFPAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY NEUROTROPHIC FACTOR; LEUKEMIA INHIBITORY FACTOR; NEUROBLASTOMA CELL-LINE; CYCLIC-AMP; SYMPATHETIC NEURONS; FACTOR RECEPTOR; CHOLINE-ACETYLTRANSFERASE; TYROSINE PHOSPHORYLATION; SIGNAL-TRANSDUCTION; MOLECULAR-CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Johnson e N.M. Nathanson, "DIFFERENTIAL REQUIREMENTS FOR P21(RAS) AND PROTEIN-KINASE-C IN THE REGULATION OF NEURONAL GENE-EXPRESSION BY NERVE GROWTH-FACTOR AND NEUROKINES", The Journal of biological chemistry, 269(29), 1994, pp. 18856-18863

Abstract

This study used reporter gene constructs containing regulatory regions of the c-fos, vasoactive intestinal peptide, and choline acetyltransferase genes to determine the role of p21(ras) and protein kinase C inthe action of ciliary neurotrophic factor and leukemia inhibitory factor. Down-regulation of protein kinase C with phorbol ester did not affect the induction of either c-fos-beta-galactosidase or vasoactive intestinal peptide-luciferase by ciliary neurotrophic factor or leukemiainhibitory factor. In contrast, while leukemia inhibitory factor induction of choline acetyltransferase-luciferase expression was protein kinase C-independent, there appears to be both protein kinase C-dependent and -independent pathways for induction of choline acetyltransferase-luciferase by ciliary neurotrophic factor. Cotransfection of a dominant-negative mutant p21(rasN17) blocked nerve growth factor-mediated induction of c-fos-beta-galactosidase, but did not affect induction of c-fos-beta-galactosidase, vasoactive intestinal peptide-luciferase, orcholine acetyltransferase-luciferase by either ciliary neurotrophic factor or leukemia inhibitory factor. Thus, in contrast to the action of nerve growth factor, gene induction by ciliary neurotrophic factor, and leukemia inhibitory factor is ras-independent in IMR-32 neuroblastoma cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:58:35