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Titolo:
EFFECT OF CIONIN ON HISTAMINE AND ACID-SECRETION BY THE PERFUSED RAT STOMACH
Autore:
MARVIK R; JOHNSEN AH; REHFELD JF; SANDVIK A; WALDUM HL;
Indirizzi:
UNIV TRONDHEIM HOSP,DEPT SURG,GASTROENTEROL SECT N-7006 TRONDHEIM NORWAY UNIV TRONDHEIM HOSP,DEPT MED N-7006 TRONDHEIM NORWAY UNIV COPENHAGEN,RIGSHOSP,DEPT CLIN BIOCHEM DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 7, volume: 29, anno: 1994,
pagine: 591 - 594
SICI:
0036-5521(1994)29:7<591:EOCOHA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ RECEPTOR; GASTRIN; RELEASE; CELLS;
Keywords:
ACID SECRETION; CHOLECYSTOKININ; CIONIN; GASTRIN; HISTAMINE; ISOLATED, VASCULARLY PERFUSED RAT STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R. Marvik et al., "EFFECT OF CIONIN ON HISTAMINE AND ACID-SECRETION BY THE PERFUSED RAT STOMACH", Scandinavian journal of gastroenterology, 29(7), 1994, pp. 591-594

Abstract

Background: The protochordean octapeptide cionin is structurally a hybrid of mammalian cholecystokinin (CCK) and gastrin. An earlier study has shown that cionin in mammals stimulates gallbladder contraction and gastric somatostatin release, similarly to CCK-8. Methods: In the present study we examined the effect of cionin on histamine release and acid secretion of the stomach, both effects being mediated by CCK-B/gastrin receptors. Results: Cionin induced a concentration-dependent increase in histamine release and acid secretion in the isolated, vascularly perfused rat stomach, detectable at a concentration of 4 pM and reaching a maximum at a concentration of 512 pM. The CCK-B/gastrin receptor antagonist L 365,260 abolished the stimulating effect of cionin onboth histamine release and acid secretion, whereas the CCK-A receptorantagonist L 364,718 only had a faint effect. Conclusion: Cionin is apotent and efficient stimulator of gastric histamine release and acidsecretion interacting via a CCK-B receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:52:41