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Titolo:
CAPSAICIN-INDUCED BLADDER HYPERACTIVITY IN NORMAL CONSCIOUS RATS
Autore:
ISHIZUKA O; IGAWA Y; MATTIASSON A; ANDERSSON KE;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN
Titolo Testata:
The Journal of urology
fascicolo: 2, volume: 152, anno: 1994,
parte:, 1
pagine: 525 - 530
SICI:
0022-5347(1994)152:2<525:CBHINC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED URINARY-BLADDER; INFRAVESICAL OUTFLOW OBSTRUCTION; TACHYKININ BINDING-SITES; MICTURITION REFLEX; SUBSTANCE-P; GUINEA-PIG; SENSITIVE NERVES; ACTIVATION; MECHANISMS; ANTAGONIST;
Keywords:
BLADDER; CAPSAICIN; TACHYKININS; RECEPTORS-NEUROKININ-1; RECEPTORS-NEUROKININ-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
O. Ishizuka et al., "CAPSAICIN-INDUCED BLADDER HYPERACTIVITY IN NORMAL CONSCIOUS RATS", The Journal of urology, 152(2), 1994, pp. 525-530

Abstract

Capsaicin, instilled intravesically in normal, unanesthetized rats induced a concentration-dependent bladder hyperactivity, which could be abolished by hexamethonium, given intraarterially near the bladder, orby morphine administered intrathecally. The effect was reversible andcould be repeated. The NK-2 receptor selective antagonist SR 48,968 and the nonselective NK receptor antagonist spantide, given intra-arterially near the bladder, which by themselves, in the concentrations used, did not affect cystometric parameters, both counteracted the capsaicin-induced hyperactivity, whereas the NK-1 receptor selective antagonist RP 67,580 failed to do so. Blockade of tachykinin receptors in theurinary bladder does not seem to produce changes of the micturition reflex associated with bladder filling in the conscious rat. However, tachykinins released from capsaicin-sensitive nerves by various stimulimay, through stimulation of NK-2 receptors, lower the threshold for initiation of the micturition reflex. In the rat, intravesical capsaicin may be a suitable model for studies of afferent activity caused by stimuli releasing peptides from sensory nerves in the bladder, thereby provoking bladder hyperactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:13:38