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Titolo:
EPITOPE-SPECIFIC ANTIBODY-RESPONSES IN MARKET-STRESSED CALVES TO BOVINE HERPESVIRUS TYPE-1
Autore:
AYERS VK; COLLINS JK; PURDY CW;
Indirizzi:
COLORADO STATE UNIV,DEPT MICROBIOL FT COLLINS CO 80523 USDA ARS,CONSERVAT & PROD RES LAB BUSHLAND TX 79012
Titolo Testata:
Vaccine
fascicolo: 10, volume: 12, anno: 1994,
pagine: 940 - 946
SICI:
0264-410X(1994)12:10<940:EAIMCT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHIPPING FEVER PNEUMONIA; MONOCLONAL-ANTIBODIES; RESPIRATORY-DISEASE; PASTEURELLA-HAEMOLYTICA; IMMUNE-RESPONSE; GLYCOPROTEINS; CATTLE; RHINOTRACHEITIS; VACCINES; TRIAL;
Keywords:
BOVINE HERPESVIRUS TYPE 1; EPITOPES; RECIPROCAL COMPETITION ELISA; VACCINATION; BOVINE RESPIRATORY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
V.K. Ayers et al., "EPITOPE-SPECIFIC ANTIBODY-RESPONSES IN MARKET-STRESSED CALVES TO BOVINE HERPESVIRUS TYPE-1", Vaccine, 12(10), 1994, pp. 940-946

Abstract

Reciprocal competition ELISA (rcELISA) was conducted to map monoclonal antibodies (mAbs) reactive with gI, gIII and gIV glycoproteins of bovine herpesvirus type 1 (BHV-1) into epitope groups. mAbs to glycoproteins gI and gIV were divided into six epitope groups each, while gill mAbs had been previously divided into four areas. mAbs were chosen from each epitope group to compete in cELISA with bovine sera collected during a typical regimen of vaccination and transportation from farm toauction to feedlot. The immunodominant epitopes were identified for each BHV-1 glycoprotein. With glycoprotein gI, three epitopes defined by mAbs 1F10, D9 and 4807 were the most dominant; with glycoprotein gIII epitopes defined by mAbs G2 and 1507, and with glycoprotein gIV epitopes defined by mAbs 1102, 1106, 3C1, 3402 and 3E7 showed the maximum responses. The overall cELISA responses to each glycoprotein among twovaccination groups were also compared and it was shown chat cELISA responses were significantly higher for each glycoprotein in calves receiving two vaccinations, one on the farm of origin and one at auction, than in calves receiving only one vaccination at auction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:51:46