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Titolo:
LOCALIZATION OF THROMBOSPONDIN, CD36 AND CD51 DURING PRENATAL DEVELOPMENT OF THE HUMAN MAMMARY-GLAND
Autore:
PECHOUX C; CLEZARDIN P; DANTE R; SERRE CM; CLERGET M; BERTIN N; LAWLER J; DELMAS PD; VAUZELLE JL; FRAPPART L;
Indirizzi:
CNRS,UPR 412,UNITE CYTOL MOLEC,PASSAGE VERCORS F-69367 LYON FRANCE CNRS,UPR 412,UNITE CYTOL MOLEC F-69367 LYON FRANCE HOP EDOUARD HERRIOT,ANAT PATHOL LAB F-69437 LYON FRANCE HOP EDOUARD HERRIOT,INSERM,RES UNIT 403 F-69437 LYON FRANCE INSERM,RES UNIT 218 F-69373 LYON FRANCE BRIGHAM & WOMENS HOSP,DIV VASC RES BOSTON MA 02115
Titolo Testata:
Differentiation
fascicolo: 2, volume: 57, anno: 1994,
pagine: 133 - 141
SICI:
0301-4681(1994)57:2<133:LOTCAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET GLYCOPROTEIN-IIIB; ARG-GLY-ASP; EXTRACELLULAR-MATRIX; CELL-ADHESION; ENDOTHELIAL-CELLS; CARCINOMA-CELLS; RECEPTOR; BINDING; ATTACHMENT; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
C. Pechoux et al., "LOCALIZATION OF THROMBOSPONDIN, CD36 AND CD51 DURING PRENATAL DEVELOPMENT OF THE HUMAN MAMMARY-GLAND", Differentiation, 57(2), 1994, pp. 133-141

Abstract

Thrombospondin (TSP) is a 450 kDa extracellular matrix glycoprotein expressed in normal, hyperplastic, and neoplastic human breast. In thisstudy, the patterns of expression of TSP were determined during development of the human fetal mammary gland between the 15th and the 39th week of gestation. Using immunohistochemistry, TSP is found in the dense mesenchyme immediately adjacent to the mammary bud, and at the membrane of budding epithelial cells invading the surrounding mesenchyme. As formation of the ductal tree system occurs, TSP is deposited at themyoepithelial-stromal junction of mammary ducts. Such an immunolocalization of TSP in buds and ducts of the fetal mammary gland has been confirmed at the mRNA level using in situ hybridization. Presence of TSPtranscripts in nascent breast tissue has been also demonstrated by polymerase chain reaction assay. Comparison of TSP immunolocalization with that of two known TSP cell surface receptors, CD36 and CD51, reveals no codistribution of TSP with these receptors during mammary gland development. As opposed to TSP, CD36 is strongly expressed at the membrane of preadipocytes present in the fat pad tissue, but absent from budding epithelial cells. CD51 is only weakly expressed by malpighian epithelial cells and does not colocalize with TSP. In lactating ducts ofa newborn, TSP disappears from the myoepithelial-stromal junction of ducts and is synthesized at the apices of secretory epithelial cells of lactating ducts together with CD36. In conclusion, our findings support the existence of an important role for TSP during development of the human fetal mammary gland. Ultimately, variations in the appearanceand distribution of TSP and CD36 during the different steps of the mammary gland developmental process may lead to changes in TSP functions, resulting in migration of budding epithelial cells or differentiation of ductal epithelial cells.

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Documento generato il 03/04/20 alle ore 03:11:34