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Titolo:
PREPARATION OF A NEW CHIRAL STATIONARY-PHASE BEARING BOTH PI-ACIDIC AND PI-BASIC SITES FROM (S)-NAPROXEN FOR THE LIQUID-CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS
Autore:
HYUN MH; JIN JS; RYOO JJ; JYUNG KK;
Indirizzi:
PUSAN NATL UNIV,DEPT CHEM PUSAN 609735 SOUTH KOREA PUSAN NATL UNIV,DEPT CHEM EDUC PUSAN 609735 SOUTH KOREA
Titolo Testata:
Bulletin of the Korean Chemical Society
fascicolo: 6, volume: 15, anno: 1994,
pagine: 497 - 502
SICI:
0253-2964(1994)15:6<497:POANCS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEPARATION; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Hyun et al., "PREPARATION OF A NEW CHIRAL STATIONARY-PHASE BEARING BOTH PI-ACIDIC AND PI-BASIC SITES FROM (S)-NAPROXEN FOR THE LIQUID-CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS", Bulletin of the Korean Chemical Society, 15(6), 1994, pp. 497-502

Abstract

A new chiral stationary phase (CSP) for the liquid chromatographic resolution of enantiomers was prepared from (S)-naproxen and 3,5-dinitroaniline. The 6-alkoxy-2-naphthyl group of the CSP was presumed to act as a n-basic interaction site for resolving pi-acidic racemates while the 3,5-dinitroanilide group of the CSP was presumed to play a role asa pi-acidic interaction site for resolving pi-basic racemates. From the chromatographic resolution trends of N-alkyl amide derivatives of alpha-arylalkylamines on the CSP prepared, the chiral recognition mode involving the intercalation of the amide alkyl chain of the less retained enantiomers between the connecting tethers of the CSP was proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:56:32