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Titolo:
PREVALENCE OF ANTIMITOCHONDRIAL ANTIBODIES IN WOMEN WITH HASHIMOTOS-THYROIDITIS
Autore:
VALLAS M; MONIER JC; TOURNIAIRE J; DAMON H; GIRARD D; BORSONCHAZOT F; SAVOYE B;
Indirizzi:
HOP ANTIQUAILLE,SERV MED INTERNE,1 RUE ANTIQUAILLE F-69321 LYON 05 FRANCE HOP ANTIQUAILLE,SERV ENDOCRINOL & MALAD NUTR LYON FRANCE FAC MED LYON,IMMUNOPATHOL LAB LYON FRANCE HOP ANTIQUAILLE,ENDOCRINOL DIABET & NUTR CLIN LYON FRANCE
Titolo Testata:
La Presse medicale
fascicolo: 24, volume: 23, anno: 1994,
pagine: 1117 - 1120
SICI:
0755-4982(1994)23:24<1117:POAAIW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; URSODEOXYCHOLIC ACID; FEATURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M. Vallas et al., "PREVALENCE OF ANTIMITOCHONDRIAL ANTIBODIES IN WOMEN WITH HASHIMOTOS-THYROIDITIS", La Presse medicale, 23(24), 1994, pp. 1117-1120

Abstract

Objectives: Thyroid antibodies are present in more than 15% of patients with primary biliary cirrhosis. Inversely, the prevalence of antimitochondrial antibodies in patients with thyroid antibodies is still unknown. The aim of the present study was to evaluate the prevalence of antimitochondrial antibodies in women positive for thyroid microsomal antibodies. Methods: Anti-thyroid microsomal positive sera were collected from 351 selected female patients (age range 40-70 years) then stored at -20 degrees C from September 91 to September 92. Anti-mitochondrial auto-antibodies were determined in all sera with enzyme-linked sorbent assay (ELISA) using purified antigen. Results: M2 antimitochondrial antibodies were found positive in 7 cases (2%). On immunoblots, the pattern of antimitochondrial reactivity visualized for the 7 sera was similar to pattern of classical primary biliary cirrhosis sera. Six of the 7 patients were asymptomatic and 4 had normal liver function tests. Liver biopsy was carried out in 2 patients and fulfilled diagnosis criteria for primary biliary cirrhosis. Six out of the 7 patients had Hashimoto's thyroiditis (2 biopsy proven, 4 clinical and biological diagnosis). Conclusion: Patients with Hashimoto's thyroiditis would bea population at high risk of primary biliary cirrhosis. It would be interesting to screen these patients in order to ascertain the signification of antimitochondrial antibody positivity, especially when there is no apparent liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:31:03