Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENDER DIFFERENCES IN THE PHENOTYPIC-EXPRESSION OF ALZHEIMERS-DISEASEIN DOWNS-SYNDROME (TRISOMY-21)
Autore:
RAGHAVAN R; KHINNU C; BROWN AG; DAY KA; TYRER SP; INCE PG; PERRY EK; PERRY RH;
Indirizzi:
NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,DEPT PSYCHIAT NEWCASTLE TYNE ENGLAND
Titolo Testata:
NeuroReport
fascicolo: 11, volume: 5, anno: 1994,
pagine: 1393 - 1396
SICI:
0959-4965(1994)5:11<1393:GDITPO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENILE DEMENTIA; ESTROGEN;
Keywords:
DOWNS SYNDROME; TRISOMY 21; GENDER; SEXUAL DIMORPHISM; ALZHEIMERS DISEASE; DEMENTIA; PLAQUES; TANGLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R. Raghavan et al., "GENDER DIFFERENCES IN THE PHENOTYPIC-EXPRESSION OF ALZHEIMERS-DISEASEIN DOWNS-SYNDROME (TRISOMY-21)", NeuroReport, 5(11), 1994, pp. 1393-1396

Abstract

TWENTY-EIGHT individuals with typical Down's syndrome (DS) phenotype (17 males and 11 females; age range: 10-74 years) were investigated for gender differences in the phenotypic expression of Alzheimer-type pathology (ATP). Quantitative neuropathology was performed in the 4 neocortical lobes of the right hemisphere, by counting senile plaques (SP), and neurofibrillary tangles (NFT). ATP was present in 25 middle-aged(> 40 years) individuals (16 males and 9 females). Females had significantly higher (p = 0.03) mean neocortical NFT densities (36.6 per mm(2); s.e.m. +/- 6.6) than males (17.9 per mm(2); s.e.m. +/-: 4.7). Noneof the females had NFT densities below 10 per mm(2), compared with 6 males in whom NFT were either absent or seen in very low densities (< 4 per mm(2)). Assessment of SP densities in the same cortical regions showed non-significant differences in females (42.4 per mm(2); s.e.m. /- 5.1) compared with males (33.6 per mm(2); s.e.m. +/- 2.1). There was clinical evidence of dementia in all the female (8/8) individuals who were prospectively assessed, compared with only 54% (7/13) of males. The male individuals without clinical dementia had absent or low neocortical NFT densities regardless of high SP densities. Female DS cases (mean age: 48.8 years; s.e.m. +/- 1.9) had an earlier onset of dementia than males (mean age: 53.6 years; s.e.m. +/- 1.3; p = 0.05). Female middle-aged DS individuals have an earlier onset, and a more severe form of AD which correlates with higher neocortical NFT rather than SPdensity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:18:00