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Titolo:
SHORT-TERM OR LONG-TERM INTRACEREBROVENTRICULAR (ICV) INFUSION OF INSULIN EXHIBITS A DISCRETE ANABOLIC EFFECT ON CEREBRAL ENERGY-METABOLISMIN THE RAT
Autore:
HENNEBERG N; HOYER S;
Indirizzi:
UNIV HEIDELBERG,DEPT PATHOCHEM & GEN NEUROCHEM,NEUENHEIMER FELD 220-221 D-69120 HEIDELBERG GERMANY UNIV HEIDELBERG,DEPT PATHOCHEM & GEN NEUROCHEM D-69120 HEIDELBERG GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 175, anno: 1994,
pagine: 153 - 156
SICI:
0304-3940(1994)175:1-2<153:SOLI(I>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; DIABETOGENIC DRUG; NERVOUS-SYSTEM; ALZHEIMER TYPE; BRAIN CORTEX; EARLY-ONSET; STREPTOZOTOCIN; DEMENTIA; GLUCOSE;
Keywords:
BRAIN ENERGY METABOLISM; INSULIN; INTRACEREBROVENTRICULAR INFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
N. Henneberg e S. Hoyer, "SHORT-TERM OR LONG-TERM INTRACEREBROVENTRICULAR (ICV) INFUSION OF INSULIN EXHIBITS A DISCRETE ANABOLIC EFFECT ON CEREBRAL ENERGY-METABOLISMIN THE RAT", Neuroscience letters, 175(1-2), 1994, pp. 153-156

Abstract

Evidence for an involvement of insulin in the regulation of cerebral glycolytic glucose catabolism is becoming more and more convincing. Toinvestigate whether short-term or long-term administration of insulinto the brain influences brain energy metabolism, we determined tissueconcentrations of energy-rich phosphates in cerebral parietotemporal cortex and in hippocampus of 1- (adult) and 2-year-old (aged) male Wistar rats treated with intracerebroventricular (i.c.v.) infusion of thehormone for 1, 7, and 21 days. In cerebral parietotemporal cortex, tissue concentrations of ATP, PCr, ADP, ATP/ADP ratio and energy charge potential were all unaltered. In hippocampus, however, the concentration of PCr was significantly increased. Thus, short-term and long-term i.c.v. administration of insulin are assumed to have a discrete anabolic effect on the cerebral energy pool.

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Documento generato il 20/01/20 alle ore 16:09:33