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Titolo:
[H-3] ROLIPRAM BINDING AND PHOSPHODIESTERASE ACTIVITY IN NEUROBLASTOMA N18TG-2 AND GLIOMA C6BU-1
Autore:
TOHDA M; MURAYAMA T; HASEGAWA H; NOGIRI S; NOMURA Y;
Indirizzi:
HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KITA KU SAPPORO 060 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KITA KU SAPPORO 060 JAPAN TOYAMA MED & PHARMACEUT UNIV,ORIENTAL MED RES INST,DEPT NEUROSCI TOYAMA 93001 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 175, anno: 1994,
pagine: 89 - 91
SICI:
0304-3940(1994)175:1-2<89:[RBAPA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE INHIBITORS; H-3 ROLIPRAM; CYCLIC-AMP; DOMAIN; CELLS;
Keywords:
PHOSPHODIESTERASE; ROLIPRAM; NEURON; GLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M. Tohda et al., "[H-3] ROLIPRAM BINDING AND PHOSPHODIESTERASE ACTIVITY IN NEUROBLASTOMA N18TG-2 AND GLIOMA C6BU-1", Neuroscience letters, 175(1-2), 1994, pp. 89-91

Abstract

To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [H-3]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells. [H-3]Rolipram binding was highly observed in cytosolic fractions of N18TG-2 compared to C6Bu-1. Binding was hardly observed in membrane fractions of both types of cells. Rolipram strongly (70%) inhibited the hydrolytic activity ofcAMP in cytosolic fractions of N18TG-2. The activity in cytosol fractions of C6Bu-1 was slightly (20%) inhibited by rolipram. These resultssuggest that PDEIV plays important roles in neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:33:48